Ghrelin Partially Protects Against Cisplatin-Induced Male Murine Gonadal Toxicity in a GHSR-1a-Dependent Manner1
Whirledge SD, Garcia JM, Smith RG, Lamb DJ. Ghrelin Partially Protects Against Cisplatin-Induced Male Murine Gonadal Toxicity in a GHSR-1a-Dependent Manner1. Biology Of Reproduction 2015, 92: 76, 1-11. PMID: 25631345, PMCID: PMC4367966, DOI: 10.1095/biolreprod.114.123570.Peer-Reviewed Original ResearchConceptsTesticular cell deathTesticular damageGonadal toxicityEpididymal weightGrowth hormone secretagogue receptorDose-dependent side effectsCisplatin-induced cachexiaTime of euthanizationHigh cumulative doseBody weight homeostasisCell deathCisplatin-induced testicular damageNovel therapeutic approachesGonadotoxin exposurePermanent azoospermiaGhrelin administrationSubsequent infertilityChemotherapeutic drug cisplatinChemotherapeutic regimensCisplatin administrationGhrelin actionWeight homeostasisCumulative doseIntraperitoneal administrationSecretagogue receptor