2007
Serotonin transporter binding after recovery from eating disorders
Bailer U, Frank G, Henry S, Price J, Meltzer C, Becker C, Ziolko S, Mathis C, Wagner A, Barbarich-Marsteller N, Putnam K, Kaye W. Serotonin transporter binding after recovery from eating disorders. Psychopharmacology 2007, 195: 315-324. PMID: 17690869, DOI: 10.1007/s00213-007-0896-7.Peer-Reviewed Original ResearchConceptsAnorexia nervosaBulimia nervosaControl womenMethodsPositron emission tomographyHealthy control womenRestricting-type anorexia nervosaRationaleSeveral linesDorsal rapheDistribution volume valuesBP valuesFunction persistEmission tomographyDisorder subjectsResultsAfter correctionMultiple comparisonsTracer kinetic modelNervosaSpecific bindingAffective regulationExaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa
Bailer U, Frank G, Henry S, Price J, Meltzer C, Mathis C, Wagner A, Thornton L, Hoge J, Ziolko S, Becker C, McConaha C, Kaye W. Exaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa. Biological Psychiatry 2007, 61: 1090-1099. PMID: 17241616, DOI: 10.1016/j.biopsych.2006.07.018.Peer-Reviewed Original ResearchConceptsPositron emission tomographyILL ANCerebral blood flowControl womenAnorexia nervosaBlood flowReceptor activityOrbital frontal regionsDorsal raphe nucleusHealthy control womenLateral temporal lobeReceptor-specific radioligandReceptor BPRaphe nucleusPoor responseSerotonin activityTemporal lobeParietal cortexEmission tomographyReceptor functionParietal regionsWomenReceptorsFrontal regionsSignificant increase
2005
Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635
Bailer U, Frank G, Henry S, Price J, Meltzer C, Weissfeld L, Mathis C, Drevets W, Wagner A, Hoge J, Ziolko S, McConaha C, Kaye W. Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635. JAMA Psychiatry 2005, 62: 1032-1041. PMID: 16143735, DOI: 10.1001/archpsyc.62.9.1032.Peer-Reviewed Original ResearchConceptsRestricting-type anorexia nervosaPositron emission tomographyAnorexia nervosaReceptor bindingEmission tomographyControl womenPathogenesis of ANDistribution volumeHealthy control womenEffects of malnutritionSerotonin neuronal activityLogan graphical methodPrefrontal cortical regionsSubgenual cingulate regionsBrain serotoninDorsal rapheReceptor antagonistSerotonergic functionBody of evidenceNeuronal activityCingulate regionsReceptor activityCortical regionsMeasures of anxietyWomenBrain imaging of serotonin after recovery from anorexia and bulimia nervosa
Kaye W, Bailer U, Frank G, Wagner A, Henry S. Brain imaging of serotonin after recovery from anorexia and bulimia nervosa. Physiology & Behavior 2005, 86: 15-17. PMID: 16102788, DOI: 10.1016/j.physbeh.2005.06.019.Peer-Reviewed Original ResearchConceptsBulimia nervosaPositron emission tomographyAnorexia nervosaReceptor functionModulation of feedingAge of onsetDegree of efficacyHomogenous presentationSerotonin pathwayGender distributionEmission tomographyBody image distortionBrain functionNew pharmacologyBrain imagingParietal regionsNervosaFood consumptionLines of evidenceSymptomsIllnessAlterationsPsychotherapy approachesPathwayFeeding behaviorIncreased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Measured by Positron Emission Tomography and [11C]Raclopride
Frank G, Bailer U, Henry S, Drevets W, Meltzer C, Price J, Mathis C, Wagner A, Hoge J, Ziolko S, Barbarich-Marsteller N, Weissfeld L, Kaye W. Increased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Measured by Positron Emission Tomography and [11C]Raclopride. Biological Psychiatry 2005, 58: 908-912. PMID: 15992780, DOI: 10.1016/j.biopsych.2005.05.003.Peer-Reviewed Original ResearchConceptsD2/D3 receptor bindingD3 receptor bindingControl womenAnorexia nervosaPositron emission tomographyDopamine D2/D3 receptor bindingD2/D3 receptor densityEmission tomographyReceptor bindingREC ANHealthy control womenD3 receptor densityEffects of malnutritionDorsal putamenAlterations of weightDorsal caudatePhysical activityReceptor densityDopamine functionMotor activityDA concentrationLines of evidenceWomenNervosaTomographySerotonin alterations in anorexia and bulimia nervosa: New insights from imaging studies
Kaye W, Frank G, Bailer U, Henry S, Meltzer C, Price J, Mathis C, Wagner A. Serotonin alterations in anorexia and bulimia nervosa: New insights from imaging studies. Physiology & Behavior 2005, 85: 73-81. PMID: 15869768, DOI: 10.1016/j.physbeh.2005.04.013.Peer-Reviewed Original ResearchConceptsBulimia nervosaAnorexia nervosaBody image distortionAge of onsetParietal cortical regionsHomogenous presentationSerotonin alterationsLimbic structuresSerotonin pathwayGender distributionCortical regionsBrain functionNew pharmacologyNervosaFood consumptionIllnessSymptomsRecent brainAlterationsRecent studiesPsychotherapy approachesBehavioral inhibitionAnxietyFeeding behaviorHedonic aspectsNeurobiology of anorexia nervosa: Clinical implications of alterations of the function of serotonin and other neuronal systems
Kaye W, Frank G, Bailer U, Henry S. Neurobiology of anorexia nervosa: Clinical implications of alterations of the function of serotonin and other neuronal systems. International Journal Of Eating Disorders 2005, 37: s15-s19. PMID: 15852312, DOI: 10.1002/eat.20109.Peer-Reviewed Original Research
2004
Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness
Bailer U, Price J, Meltzer C, Mathis C, Frank G, Weissfeld L, McConaha C, Henry S, Brooks-Achenbach S, Barbarich N, Kaye W. Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness. Neuropsychopharmacology 2004, 29: 1143-1155. PMID: 15054474, PMCID: PMC4301578, DOI: 10.1038/sj.npp.1300430.Peer-Reviewed Original ResearchConceptsControl womenAnorexia nervosaPositron emission tomographyBulimia nervosaBrain serotonin 2A (5-HT(2A)) receptorsMajor depressive disorder diagnosisDisturbances of appetiteLeft subgenual cingulateHealthy control womenDepressive disorder diagnosisEffects of malnutritionSerotonin 2A receptorRight occipital cortexLeft parietal cortexSubgenual cingulate regionsAN-BNReceptor antagonistNeuronal pathwaysSubgenual cingulateOccipital cortexHigh incidenceCingulate regionsParietal cortexCortical regionsEmission tomography