2012
PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring
Wang J, Aksoy S. PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 10552-10557. PMID: 22689989, PMCID: PMC3387098, DOI: 10.1073/pnas.1116431109.Peer-Reviewed Original ResearchConceptsMother's milkImmune deficiency (IMD) pathwayPGRP-LBHost immune systemImmune system developmentIntrauterine environmentNutritional supplementationDietary supplementationHyperimmune responseImmune systemImpact immunityNewborn progenyParasite infectionAdultsParasitized adultsPeptidoglycan recognition proteinsSuch adultsImmunitySupplementationAntitrypanosomal activityPivotal roleMilkInductionHost fecundityMilk proteins
2011
Tsetse Immune System Maturation Requires the Presence of Obligate Symbionts in Larvae
Weiss BL, Wang J, Aksoy S. Tsetse Immune System Maturation Requires the Presence of Obligate Symbionts in Larvae. PLOS Biology 2011, 9: e1000619. PMID: 21655301, PMCID: PMC3104962, DOI: 10.1371/journal.pbio.1000619.Peer-Reviewed Original ResearchConceptsIntrauterine larvaeBeneficial microbial symbiontsSpecific host phenotypesMilk gland secretionsHost physiological processesCo-evolutionary adaptationMicrobial symbiontsWigglesworthia glossinidiaObligate mutualistsHost phenotypePhysiological processesImmune system homeostasisWigglesworthiaTsetse fliesImportant functionsGland secretionSystem homeostasisFliesGlossina morsitansMutualistsSymbiontsDietary supplementationLarvaeHomeostasisPhenotype