2020
Oligometastatic Disease and Local Therapies: A Medical Oncology Perspective.
Hafez N, Gettinger S. Oligometastatic Disease and Local Therapies: A Medical Oncology Perspective. The Cancer Journal 2020, 26: 144-148. PMID: 32205539, DOI: 10.1097/ppo.0000000000000439.Peer-Reviewed Original ResearchConceptsAggressive local therapySubset of patientsLocal therapyOligometastatic diseaseCancer patientsNon-small cell lung cancer patientsOligometastatic colorectal cancer (CRC) patientsCell lung cancer patientsLong-term disease remissionStereotactic body radiation therapyLimited nodal involvementMedical oncology perspectiveDefinitive local therapyColorectal cancer patientsSolid tumor patientsLung cancer patientsSolid tumor malignanciesBody radiation therapyDisease remissionOligometastatic statePrimary therapyNodal involvementOverall survivalSystemic therapyMetastatic sites
2014
B7-H1/PD-1 Blockade Therapy in Non–Small Cell Lung Cancer
Gettinger S, Herbst RS. B7-H1/PD-1 Blockade Therapy in Non–Small Cell Lung Cancer. The Cancer Journal 2014, 20: 281-289. PMID: 25098289, DOI: 10.1097/ppo.0000000000000063.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerAdvanced non-small cell lung cancerPhase III trialsCell lung cancerIII trialsPD-1Lung cancerClinical trialsPD-1/PD-L1 inhibitorsB7-H1/PDTumor PD-L1 expressionSevere autoimmune toxicityChemotherapy-naive patientsPD-L1 expressionPotential of immunotherapyPD-L1 inhibitorsDeath ligand 1Future clinical trialsNumber of antibodiesAutoimmune toxicityExpansion cohortBlockade therapyDurable responsesNSCLC patientsStandard therapy
2012
Immune Therapies for Lung Cancer
Gettinger S. Immune Therapies for Lung Cancer. Journal Of Thoracic Oncology 2012, 7: s394-s396. PMID: 23160331, DOI: 10.1097/jto.0b013e31826df203.Peer-Reviewed Original Research
2011
HER-1, 2, and 3
Gettinger S. HER-1, 2, and 3. Journal Of Thoracic Oncology 2011, 6: s1793-s1796. PMID: 22005533, DOI: 10.1097/01.jto.0000407561.68910.a1.Peer-Reviewed Original ResearchAntineoplastic AgentsClinical Trials as TopicErbB ReceptorsHumansNeoplasmsReceptor, ErbB-2Receptor, ErbB-3
2010
Targeted therapy for thyroid cancer: An updated review of investigational agents.
Deshpande HA, Gettinger SN, Sosa JA. Targeted therapy for thyroid cancer: An updated review of investigational agents. Current Opinion In Investigational Drugs 2010, 11: 661-8. PMID: 20496261.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsClinical Trials as TopicDrugs, InvestigationalHumansMolecular Targeted TherapyThyroid NeoplasmsConceptsMedullary thyroid cancerThyroid cancerEarly phase clinical trialsPapillary thyroid cancerRandomized trialsInvestigational agentsClinical trialsTargeted therapyPotential therapyPromising drugXL-184CancerTreatmentUpdated reviewTherapyTrialsMolecular mechanismsSunitinibMalignancySorafenibVandetanibBRAFVEGFRCarcinogenesisManagement of Patients with Advanced Non-Small Cell Lung Cancer
Triano LR, Deshpande H, Gettinger SN. Management of Patients with Advanced Non-Small Cell Lung Cancer. Drugs 2010, 70: 167-179. PMID: 20108990, DOI: 10.2165/11532200-000000000-00000.Peer-Reviewed Original ResearchConceptsAdvanced non-small cell lung cancerNon-small cell lung cancerCell lung cancerEpidermal growth factor receptorGrowth factor receptorOverall survivalLung cancerThird-line treatmentFirst-line chemotherapyFactor receptorManagement of patientsVascular endothelial growth factorQuality of lifeEndothelial growth factorMedian survivalSystemic therapyRandomized trialsTraditional chemotherapySmall molecule inhibitorsFDA approvalUS FDAChemotherapyKey mediatorGrowth factorAdditional agents
2008
Novel chemotherapy options for advanced thyroid tumors: small molecules offer great hope
Deshpande HA, Gettinger SN, Sosa JA. Novel chemotherapy options for advanced thyroid tumors: small molecules offer great hope. Current Opinion In Oncology 2008, 20: 19-24. PMID: 18043252, DOI: 10.1097/cco.0b013e3282f28373.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAntineoplastic AgentsCarcinoma, MedullaryClinical Trials as TopicHumansThyroid NeoplasmsTomography, X-Ray ComputedConceptsThyroid cancerClinical trialsAdvanced thyroid tumorsAdvanced thyroid cancerFurther clinical trialsMedullary thyroid cancerRandomized clinical trialsAblative radiation therapyEpidermal growth factor receptorInhibitors of angiogenesisGrowth factor receptorChemotherapy optionsMedical oncologistsEndocrine tumorsConventional chemotherapyRET inhibitionEndocrine cancersEndocrine malignancyRadiation therapyThyroid tumorsAntiangiogenesis strategiesNatural historyCancerFactor receptorRET protein