2022
An outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era
Roberts SC, Palacios C, Grubaugh ND, Alpert T, Ott IM, Breban MI, Initiative Y, Martinello RA, Smith C, Davis MW, Mcmanus D, Tirmizi S, Topal JE, Azar MM, Malinis M. An outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era. Transplant Infectious Disease 2022, 24: e13782. PMID: 34969164, DOI: 10.1111/tid.13782.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Infection prevention practicesSARS-CoV-2 outbreakTransplant unitCOVID-19-associated morbiditySolid organ transplant recipientsSARS-CoV-2 vaccinationPrevention practicesHospital day 18Potential index casesOrgan transplant recipientsInfection prevention behaviorsMonoclonal antibody therapyCOVID-19SARS-CoV-2 clustersHospital staff membersWhole-genome sequencingAsymptomatic patientsTransplant recipientsPositive patientsAtypical presentationImmunocompromised patientsAntibody therapyVaccination eraDisease progression
2020
520. Longitudinal Analysis of SARS-CoV-2 Viruses in Hospitalized Adults
Simons L, Lorenzo-Redondo R, Nam H, Roberts S, Ison M, Achenbach C, Hauser A, Ozer E, Hultquist J. 520. Longitudinal Analysis of SARS-CoV-2 Viruses in Hospitalized Adults. Open Forum Infectious Diseases 2020, 7: s325-s326. PMCID: PMC7776408, DOI: 10.1093/ofid/ofaa439.714.Peer-Reviewed Original ResearchSARS-CoV-2 viral loadViral loadSARS-CoV-2Hospitalized adultsPositive SARS-CoV-2 testSARS-CoV-2 testWhole viral genome sequencingNasopharyngeal viral loadResults 60 patientsNorthwestern Memorial HospitalCoronavirus disease 2019Viral load dataSARS-CoV-2 virusImmune selective pressureViral genome sequencingQuantitative reverse transcriptase PCRReverse transcriptase-PCRNasopharyngeal specimensNasopharyngeal swabsMemorial HospitalClinical dataIndividual patientsClinical consequencesDisease 2019Immune pressure516. SARS-CoV-2 Exhibits Clade-specific Differences in Nasopharyngeal Viral Loads
Nam H, Lorenzo-Redondo R, Roberts S, Simons L, Achenbach C, Hauser A, Ison M, Hultquist J, Ozer E. 516. SARS-CoV-2 Exhibits Clade-specific Differences in Nasopharyngeal Viral Loads. Open Forum Infectious Diseases 2020, 7: s324-s324. PMCID: PMC7776718, DOI: 10.1093/ofid/ofaa439.710.Peer-Reviewed Original ResearchNasopharyngeal viral loadViral loadClinical significancePositive SARS-CoV-2 RTSARS-CoV-2 RTCoronavirus disease 2019Further longitudinal studiesNorthwestern Memorial HospitalSARS-CoV-2 isolatesCT valuesSARS-CoV-2SARS-CoV-2 genotypesClade 1 virusesViral cladesClade 2 virusesSymptom onsetClinical parametersNasopharyngeal swabsUpper airwayMemorial HospitalDistinct viral cladesClinical dataDisease 2019540. Prolonged Viral Shedding of SARS-CoV-2 In Solid Organ Transplant Recipients
Nam H, Roberts S, Tanna S, Ison M. 540. Prolonged Viral Shedding of SARS-CoV-2 In Solid Organ Transplant Recipients. Open Forum Infectious Diseases 2020, 7: s337-s337. PMCID: PMC7777463, DOI: 10.1093/ofid/ofaa439.734.Peer-Reviewed Original ResearchSolid organ transplant recipientsOrgan transplant recipientsViral sheddingSevere diseaseTransplant recipientsSARS-CoV-2SOT recipientsMedian durationPositive SARS-CoV-2 PCR testPositive SARS-CoV-2 RTSARS-CoV-2 PCR resultSARS-CoV-2 PCR testSARS-CoV-2 PCR positivitySARS-CoV-2 infectionSARS-CoV-2 RTKidney transplant recipientsMajority of patientsConclusion COVID-19COVID-19African American/BlackKidney recipientsSOT patientsMedian ageModerate diseaseOverall mortalityA clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways
Lorenzo-Redondo R, Nam HH, Roberts SC, Simons LM, Jennings LJ, Qi C, Achenbach CJ, Hauser AR, Ison MG, Hultquist JF, Ozer EA. A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways. EBioMedicine 2020, 62: 103112. PMID: 33186810, PMCID: PMC7655495, DOI: 10.1016/j.ebiom.2020.103112.Peer-Reviewed Original ResearchConceptsPatient's upper airwayViral loadSARS-CoV-2Upper airwayHighest average viral loadSARS-CoV-2 infectionTranslational Research AwardTime of diagnosisAverage viral loadCOVID-19 patientsLow viral loadComprehensive cancer centerCoronavirus disease 2019SARS-CoV-2 isolatesSARS-CoV-2 virusClade 1 virusesClade 2 virusesRelative viral loadVirologic featuresClinical characteristicsClinical parametersCancer CenterDistinct viral cladesClinical significanceTranslational Science Institute