2001
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol44Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase.
Palom Y, Belcourt M, Tang L, Mehta S, Sartorelli A, Pritsos C, Pritsos K, Rockwell S, Tomasz M. Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol44Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase. Biochemical Pharmacology 2001, 61: 1517-1529. PMID: 11377381, DOI: 10.1016/s0006-2952(01)00609-8.Peer-Reviewed Original Research
1987
Effects of the mode of administration of mitomycin on tumor and marrow response and on the therapeutic ratio.
Rockwell S, Nierenburg M, Irvin C. Effects of the mode of administration of mitomycin on tumor and marrow response and on the therapeutic ratio. Journal Of The National Cancer Institute 1987, 71: 927-34. PMID: 3652056.Peer-Reviewed Original ResearchConceptsDoses of mitomycinTherapeutic ratioSingle injectionDaily injectionsAntineoplastic effectsSurvival curvesEMT6 mouse mammary tumorsHost toxicityBALB/c miceLarge single doseTumor growth assaysEffect of mitomycinLess host toxicityMouse mammary tumorsResponse of tumorsBone marrow stem cellsMode of administrationMarrow stem cellsSublethal lesionsMarrow responseDaily fractionsSingle doseTumor responseC miceClinical impression