2009
Hypoxia and radiation therapy: past history, ongoing research, and future promise.
Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT. Hypoxia and radiation therapy: past history, ongoing research, and future promise. 2009, 9: 442-58. PMID: 19519402, PMCID: PMC2752413, DOI: 10.2174/156652409788167087.Peer-Reviewed Original ResearchConceptsClinical trialsSolid tumorsLarge bulky tumorsMicroscopic tumor involvementSmall primary tumorsSelection of patientsOutcome of treatmentNovel therapeutic approachesNew therapeutic targetsEffects of hypoxiaHypoxic tumor cellsTumor oxygen levelsSurgical marginsTumor involvementBulky tumorsTreatment regimensPrimary tumorVascular bedClinical studiesExtensive necrosisRadiation therapyTherapeutic approachesNew agentsTherapeutic targetTherapeutic resistance
1991
Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur)
Rockwell S, Grindey G. Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur). Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 1991, 3: 103-108. PMID: 2025495, DOI: 10.3727/095535491820873434.Peer-Reviewed Original ResearchConceptsEMT6 mouse mammary tumor cellsMouse mammary tumor cellsMammary tumor cellsAcute hypoxiaSolid tumorsSulofenurTumor cellsCytotoxic effectsCulture mediumVitro studyPlateau-phase culturesDiarylsulfonylureasCytotoxicityDrugsFurther examinationProliferative stateMonolayer culturesQuiescent cellsTreatmentCritical determinantCellsRadiotherapy