2013
Lasalocid induces apoptosis via the cell cycle arrest and ROS‐mediated mitochondrial pathway in prostate cancer PC‐3 cells
Kim K, Kim S, Yu S, Park S, Kong2 I, Ahn S. Lasalocid induces apoptosis via the cell cycle arrest and ROS‐mediated mitochondrial pathway in prostate cancer PC‐3 cells. The FASEB Journal 2013, 27: lb206-lb206. DOI: 10.1096/fasebj.27.1_supplement.lb206.Peer-Reviewed Original ResearchProstate cancer cellsHuman prostate cancer cellsCancer cellsPC-3 cellsCaspase-3 substrateMitochondrial membrane hyperpolarizationCaspase-dependent apoptosisMitochondrial membrane potentialCell cycle arrestProstate cancer PC-3 cellsCancer PC-3 cellsMitochondrial pathwayIntracellular ROS levelsTriggers apoptosisLevels of BaxPARP-1Cycle arrestSignal pathwayAssociated signal pathwayROS levelsCaspase-3Bcl-2ApoptosisElevated oxidative stressMembrane potential
2011
Silibinin Inhibits Cell Growth and Induces Apoptosis through Cell-cycle Arrest in PC-3 Prostate Cancer Cells
Kim S, Kim K, Yu S, Jeon H, Jin Y, Lee C, Ahn S. Silibinin Inhibits Cell Growth and Induces Apoptosis through Cell-cycle Arrest in PC-3 Prostate Cancer Cells. Journal Of Life Science 2011, 21: 1573-1578. DOI: 10.5352/jls.2011.21.11.1573.Peer-Reviewed Original ResearchCell cycle check point proteinsCell cycle arrestDose-dependent mannerCheck point proteinsPC-3Cycle arrestProstate cancer cell line PC-3Cancer cell line PC-3Cyclin-dependent kinases 2/4/6PC-3 prostate cancer cellsCell line PC-3Milk thistleProstate cancer cells PC-3Prostate cancer cellsPC-3 cellsPI double stainingCancer cell linesCell growthInhibits cell growthChemopreventive effectsPoly (ADP-ribose) polymerase cleavageAnticancer effectsFlow cytometryRadical scavenger activityCaspase-3 activation