Featured Publications
RPSA, a candidate gene for isolated congenital asplenia, is required for pre-rRNA processing and spleen formation in Xenopus
Griffin JN, Sondalle SB, Robson A, Mis EK, Griffin G, Kulkarni SS, Deniz E, Baserga SJ, Khokha MK. RPSA, a candidate gene for isolated congenital asplenia, is required for pre-rRNA processing and spleen formation in Xenopus. Development 2018, 145: dev166181. PMID: 30337486, PMCID: PMC6215398, DOI: 10.1242/dev.166181.Peer-Reviewed Original ResearchConceptsPre-rRNA processingSmall ribosomal subunitCommon disease-associated mutationDisease-associated mutationsRpsA mRNARibosome biogenesisRibosome productionRibosome functionRibosomal subunitCandidate genesHuman mRNAsProtein componentsImpairs expressionSpleen developmentMolecular patterningRPSASpleen anlageMutationsXenopusGenesFirst animal modelUniversal requirementMRNAThe pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma
Tao T, Sondalle SB, Shi H, Zhu S, Perez-Atayde AR, Peng J, Baserga SJ, Look AT. The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. Oncogene 2017, 36: 3852-3867. PMID: 28263972, PMCID: PMC5501763, DOI: 10.1038/onc.2016.527.Peer-Reviewed Original ResearchConceptsDigestive organ expansion factorSmall ribosomal subunitPeripheral sympathetic nervous systemPre-ribosomal RNA processingTransgenic zebrafish modelOverexpression of MYCNNeuroblastoma cellsRibosome biogenesisSSU processomeNucleolar factorsRNA processingSympathetic nervous systemRibosomal subunitZebrafish modelHuman neuroblastoma cell lineTumor growth rateHuman neuroblastoma cellsNeuroblastoma cell linesNovel siteZebrafishCell linesNervous systemHuman neuroblastomaDisease penetranceNeuroblastoma
2023
Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing
McCool M, Bryant C, Huang H, Ogawa L, Farley-Barnes K, Sondalle S, Abriola L, Surovtseva Y, Baserga S. Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing. RNA Biology 2023, 20: 257-271. PMID: 37246770, PMCID: PMC10228412, DOI: 10.1080/15476286.2023.2217392.Peer-Reviewed Original ResearchMeSH KeywordsHumansNuclear ProteinsRNA PrecursorsRNA Processing, Post-TranscriptionalRNA, Ribosomal, 18SRNA, Small NucleolarSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsConceptsPre-rRNA accumulationRibosome biogenesisNonessential roleEukaryotic ribosome biogenesisEssential cellular processesNucleolar stress responsePre-rRNA levelsRRNA processingLikely orthologCellular processesAssociated proteinsTumor suppressorStress responseHuman cellsProtein synthesisProtein 7Human counterpartBiogenesisYeastOrthologsHomologSubcomplexAccumulationRRNATranscription