2023
Specific Intratumor Bacteria Genera and TRG Recombinations Associated with Greater Survival Probability in Alimentary Tract Cancers
Zaman S, Chobrutskiy B, Quach J, Blanck G. Specific Intratumor Bacteria Genera and TRG Recombinations Associated with Greater Survival Probability in Alimentary Tract Cancers. Journal Of Gastrointestinal Cancer 2023, 54: 1300-1307. PMID: 37103748, DOI: 10.1007/s12029-023-00935-2.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaEsophageal NeoplasmsHumansProbabilityRecombination, GeneticStomach NeoplasmsConceptsT-cell infiltratesStomach adenocarcinomaGamma delta T cellsCox proportional hazards modelAlimentary tract cancersTumor immune milieuProportional hazards modelPrimary tumor samplesImmune milieuOS probabilityCancer Genome AtlasCell infiltrateTract cancerPatient survivalEsophageal cancerPrimary tumorCancer DatabaseT cellsHazards modelTumor samplesExome filesAlimentary tractGenome AtlasBacterial infiltrationInfiltratesAppendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival study
Chen G, Chen K, Sahyoun L, Zaman S, Protiva P. Appendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival study. BMJ Open Gastroenterology 2023, 10: e001045. PMID: 36822658, PMCID: PMC9950880, DOI: 10.1136/bmjgast-2022-001045.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAppendiceal NeoplasmsColonic NeoplasmsColorectal NeoplasmsHumansMaleNeoplasm StagingPrognosisConceptsCecal adenocarcinomaAppendiceal adenocarcinomaCox regression analysisAppendiceal cancerMantel-Haenszel log-rank testColorectal cancer screening ratesMultivariable Cox regression analysisCounty-level socioeconomic factorsCancer screening ratesEnd Results (SEER) databaseKaplan-Meier methodRare gastrointestinal malignancyLog-rank testNon-mucinous histologySingle marital statusNon-Hispanic ethnicityYears of ageComparative survival analysisComparative survival studyRegression analysisSAS V.9.4Gastrointestinal malignanciesOverall survivalBetter prognosisChemotherapy protocols
2020
Immunogenomics of colorectal adenocarcinoma: Survival distinctions represented by immune receptor, CDR3 chemical features and high expression of BTN gene family members
Diaz MJ, Chobrutskiy BI, Zaman S, Blanck G. Immunogenomics of colorectal adenocarcinoma: Survival distinctions represented by immune receptor, CDR3 chemical features and high expression of BTN gene family members. Cancer Treatment And Research Communications 2020, 24: 100196. PMID: 32769037, DOI: 10.1016/j.ctarc.2020.100196.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAftercareAntineoplastic Agents, ImmunologicalBiomarkers, TumorButyrophilinsColorectal NeoplasmsComplementarity Determining RegionsComputational BiologyDisease-Free SurvivalExomeGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateReceptors, Antigen, B-CellReceptors, Antigen, T-CellRecombination, GeneticRNA-SeqSurvival RateConceptsSurvival rateLung cancerColon cancerImmune receptor recombinationsWorse survival rateCancer survival ratesCases of melanomaBetter survival rateB cell receptorFamily membersSurvival distinctionsCancer Genome AtlasImmunotherapy approachesColorectal adenocarcinomaT cellsImmunogenomics studiesCancer typesCancerConsistent associationHigh expressionGenome AtlasImmune receptorsImmunogenomic featuresMelanomaCancer exomes