2012
Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis
Akbay EA, Peña CG, Ruder D, Michel JA, Nakada Y, Pathak S, Multani AS, Chang S, Castrillon DH. Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis. Oncogene 2012, 32: 2211-2219. PMID: 22689059, PMCID: PMC3636499, DOI: 10.1038/onc.2012.232.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAnimalsCarcinoma, EndometrioidCell Transformation, NeoplasticDisease Models, AnimalDNA Breaks, Double-StrandedDNA-Binding ProteinsEndometrial NeoplasmsFemaleHumansMiceMice, TransgenicShelterin ComplexTelomere HomeostasisTelomere-Binding ProteinsTumor Cells, CulturedTumor Suppressor Protein p53ConceptsType II endometrial cancerEndometrial intraepithelial carcinomaEndometrial cancerEndometrial adenocarcinomaEndometrial carcinogenesisTelomerase-null miceProminent nuclear atypiaType II tumorsMulti-organ failureType II cancersInvasive endometrial adenocarcinomaMonths of ageMetastatic diseaseII tumorsEndometrial lesionsIntraepithelial carcinomaEndometrial epitheliumNuclear atypiaTumorsAdenocarcinomaVivo correlatesDetectable DNA damageHuman tumorsMiceLesions
2003
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
Liu G, Parant J, Lang G, Chau P, Chavez-Reyes A, El-Naggar A, Multani A, Chang S, Lozano G. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nature Genetics 2003, 36: 63-68. PMID: 14702042, DOI: 10.1038/ng1282.Peer-Reviewed Original ResearchConceptsTrp53-null miceCell cycle arrestEarly onsetCycle arrestPartial cell cycle arrestMonths of ageTrp53 mutant miceSpontaneous tumorsSpontaneous tumorigenesisRare mutant formMutant miceThymic lymphomasMiceHuman tumorsSuppression of tumorigenesisTumorsAbsence of apoptosisP53 proteinP53-dependent apoptosisInduces ApoptosisLymphomaApoptosisTumorigenesisTumor suppressorP53-induced apoptosis