1998
Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1
Halaban R, Cheng E, Zhang Y, Mandigo C, Miglarese M. Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1. Oncogene 1998, 16: 2489-2501. PMID: 9627115, DOI: 10.1038/sj.onc.1201773.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CycleCell Cycle ProteinsCell SurvivalCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21CyclinsDNA-Binding ProteinsE2F Transcription FactorsE2F1 Transcription FactorGene Expression RegulationHumansMelanocytesMiceMice, NudeMutagenesisProtein BiosynthesisRecombinant Fusion ProteinsRetinoblastoma ProteinRetinoblastoma-Binding Protein 1Tetradecanoylphorbol AcetateTranscription Factor DP1Transcription FactorsConceptsP21WAF1/CIP1Cell cycle progressionMouse melanocytesTarget genesCycle progressionRetinoblastoma tumor suppressor proteinE2F-mediated transactivationCell cycle constraintsTumor suppressor proteinRole of E2F1Deletion of p16INK4AFree E2FExpression of RbGene disruptionSuppressor proteinEctopic expressionHallmark of melanomaTetradecanoyl phorbol 13Loss of p16INK4aConstitutive expressionMelanoma cell linesCell deathNormal melanocytesIndependent growthMelanocyte growth
1993
Pigmentation and Proliferation of Human Melanocytes and the Effects of Melanocyte‐Stimulating Hormone and Ultraviolet B Lighta
HALABAN R, TYRRELL L, LONGLEY J, YARDEN Y, RUBIN J. Pigmentation and Proliferation of Human Melanocytes and the Effects of Melanocyte‐Stimulating Hormone and Ultraviolet B Lighta. Annals Of The New York Academy Of Sciences 1993, 680: 290-301. PMID: 7685575, DOI: 10.1111/j.1749-6632.1993.tb19691.x.Peer-Reviewed Original Research
1987
Transplantation of Human Melanocytes
Lerner A, Halaban R, Klaus S, Moellmann G. Transplantation of Human Melanocytes. Journal Of Investigative Dermatology 1987, 89: 219-224. PMID: 3624895, DOI: 10.1111/1523-1747.ep12470973.Peer-Reviewed Original ResearchMeSH KeywordsAdultCells, CulturedHumansMaleMelanocytesMicroscopy, ElectronPigmentation DisordersSkinTetradecanoylphorbol AcetateNormal murine melanocytes in culture
Tamura A, Halaban R, Moellmann G, Cowan J, Lerner M, Lerner A. Normal murine melanocytes in culture. In Vitro Cellular & Developmental Biology 1987, 23: 519-522. PMID: 3610949, DOI: 10.1007/bf02628423.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell DivisionCells, CulturedCulture TechniquesDNA ReplicationKaryotypingKineticsMelanocytesMiceMice, Inbred StrainsSpecies SpecificityTetradecanoylphorbol Acetate
1986
Phorbol Ester Serves As a Coepibolin in the Spreading of Primary Guinea Pig Epidermal Cells
Stenn K, Core N, Halaban R. Phorbol Ester Serves As a Coepibolin in the Spreading of Primary Guinea Pig Epidermal Cells. Journal Of Investigative Dermatology 1986, 87: 754-757. PMID: 2431072, DOI: 10.1111/1523-1747.ep12456946.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiglyceridesEpidermal CellsGlycoproteinsGuinea PigsOvalbuminPhorbol EstersSerum AlbuminTetradecanoylphorbol AcetateVitronectinHuman Melanocytes Cultured from Nevi and Melanomas
Halaban R, Ghosh S, Duray P, Kirkwood J, Lerner A. Human Melanocytes Cultured from Nevi and Melanomas. Journal Of Investigative Dermatology 1986, 87: 95-101. PMID: 2425008, DOI: 10.1111/1523-1747.ep12523594.Peer-Reviewed Original ResearchConceptsPresence of mitogensHuman melanocytesNeonatal melanocytesRate of proliferationPrimary melanomaCongenital neviMalignant transformationTransformation of melanocytesCholera toxinIsobutylmethyl xanthineHuman placentaGrowth factorProliferative rateMelanomaNewborn foreskinUnidentified factorsCell linesMelanocytesMitogenNeviHuman neonatal melanocytesPopulation doublingsMonthsLate eventProliferation