Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study
McNamara R, Schurdak J, Asch R, Lindquist D. Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study. Nutritional Neuroscience 2017, 22: 587-595. PMID: 29286866, PMCID: PMC6251752, DOI: 10.1080/1028415x.2017.1419550.Peer-Reviewed Original ResearchConceptsDEF ratsFO ratsAMPH challengeAmphetamine treatmentDocosahexaenoic acidBOLD activationDHA levelsBilateral caudate putamenBrain DHA levelsErythrocyte DHA levelsNeuroplastic brain changesPharmacological magnetic resonanceBlood oxygen level-dependent (BOLD) responseAlpha-linolenic acidAttention deficit hyperactivity disorderLevel-dependent responsesGreater locomotor activityDeficit hyperactivity disorderDEF animalsBrain activation patternsPhMRI studiesAMPH injectionFatty acidsAMPH exposureBasal forebrainDeficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study
McNamara R, Schurdak J, Asch R, Peters B, Lindquist D. Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study. Developmental Neuroscience 2017, 40: 84-92. PMID: 29216635, DOI: 10.1159/000484554.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiffusion Tensor ImagingDocosahexaenoic AcidsMaleNeurogenesisProsencephalonRatsRats, Long-EvansWhite MatterConceptsWhite matter integrityDEF ratsRight external capsuleTract-based spatial statisticsGreater radial diffusivityCON ratsExternal capsuleProinflammatory signalingDiffusion tensor imagingProinflammatory markersRadial diffusivityFO ratsMyelin basic protein mRNA expressionLower CRP levelsDiffusion tensor imaging studyVoxelwise tract-based spatial statisticsBrain white matter integrityWhite matter microstructural integrityCorpus callosum genuProtein mRNA expressionBrain DHAPeriadolescent developmentCRP levelsFatty acidsMale rats