2013
Evaluation of Novel Orthotopic Nude Mouse Models for Human Small-Cell Lung Cancer
Isobe T, Onn A, Morgensztern D, Jacoby JJ, Wu W, Shintani T, Itasaka S, Shibuya K, Koo PJ, O'Reilly MS, Herbst RS. Evaluation of Novel Orthotopic Nude Mouse Models for Human Small-Cell Lung Cancer. Journal Of Thoracic Oncology 2013, 8: 140-146. PMID: 23328546, DOI: 10.1097/jto.0b013e3182725ff9.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerHuman small cell lung cancerLymph nodesLung cancerMurine modelOrthotopic nude mouse modelHuman SCLC tumorsAxillary lymph nodesOrthotopic murine modelNovel therapeutic strategiesSubcutaneous xenograft modelTumor growth patternNude mouse modelEffective murine modelLeft lungRight lungTumor sizeSolitary massSCLC tumorsOrthotopic modelMouse modelNew therapiesTherapeutic strategiesXenograft modelNude mice
2007
Targeted Therapy Against VEGFR and EGFR With ZD6474 Enhances the Therapeutic Efficacy of Irradiation in an Orthotopic Model of Human Non–Small-Cell Lung Cancer
Shibuya K, Komaki R, Shintani T, Itasaka S, Ryan A, Jürgensmeier JM, Milas L, Ang K, Herbst RS, O'Reilly MS. Targeted Therapy Against VEGFR and EGFR With ZD6474 Enhances the Therapeutic Efficacy of Irradiation in an Orthotopic Model of Human Non–Small-Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2007, 69: 1534-1543. PMID: 17889445, PMCID: PMC2151850, DOI: 10.1016/j.ijrobp.2007.07.2350.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorCell ProliferationCombined Modality TherapyDNA RepairEpidermal Growth FactorErbB ReceptorsFeasibility StudiesHumansLung NeoplasmsMaleMiceMice, NudeNeovascularization, PathologicPiperidinesPleural EffusionQuinazolinesRadiation ToleranceRadiation-Sensitizing AgentsReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2Xenograft Model Antitumor AssaysConceptsVascular endothelial growth factor receptor 2Epidermal growth factor receptorLung cancerHuman lung cancerOrthotopic modelRadiation therapyHuman lung adenocarcinoma cellsLung adenocarcinoma cellsConventional therapyAntitumor effectsOrthotopic human lung cancer modelNon-small cell lung cancerHuman non-small cell lung cancerHuman lung cancer modelAdenocarcinoma cellsGrowth factor receptor 2Lung tumor burdenLung cancer modelEndothelial growth factor receptor 2Pleural effusion formationFactor receptor 2Basic fibroblast growth factorMatrix metalloproteinase-2Human lung adenocarcinomaSublethal damage repair
2003
Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice.
Onn A, Isobe T, Itasaka S, Wu W, O'Reilly MS, Ki Hong W, Fidler IJ, Herbst RS. Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice. Clinical Cancer Research 2003, 9: 5532-9. PMID: 14654533.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Non-Small-Cell LungCarcinoma, Small CellCarcinoma, Squamous CellCell Line, TumorFibroblast Growth Factor 2HumansInterleukin-8Lung NeoplasmsLymphatic MetastasisMiceMice, NudeModels, BiologicalNeoplasm MetastasisNeovascularization, PathologicPaclitaxelVascular Endothelial Growth Factor AConceptsNon-small cell lung cancerHuman lung cancerCell lung cancerLung cancerOrthotopic modelNude miceHuman primary lung cancerPrimary human lung cancersSmall cell lung cancer cellsExtrathoracic lymph nodesCell lung cancer cellsPrimary lung cancerSquamous cell carcinomaLung cancer cell linesLung cancer biologyVascular endothelial growth factor/vascular permeability factorLimited therapeutic responseRelevant animal modelsNovel therapeutic strategiesBasic fibroblast growth factorCell lung cancer biologyHuman lung adenocarcinomaLung cancer cellsLung cancer tumorsVascular permeability factorO-290 Blockade of EGFR tyrosine kinase does not predict outcome in a new orthotopic model of human lung cancer
Onn A, Isobe T, Itasaka S, Wu W, O'Reilly M, Fidler I, Herbst R. O-290 Blockade of EGFR tyrosine kinase does not predict outcome in a new orthotopic model of human lung cancer. Lung Cancer 2003, 41: s84-s85. DOI: 10.1016/s0169-5002(03)91948-9.Peer-Reviewed Original Research