2014
New Strategies in Personalized Medicine for Solid Tumors: Molecular Markers and Clinical Trial Designs
Jürgensmeier JM, Eder JP, Herbst RS. New Strategies in Personalized Medicine for Solid Tumors: Molecular Markers and Clinical Trial Designs. Clinical Cancer Research 2014, 20: 4425-4435. PMID: 25183480, PMCID: PMC5369358, DOI: 10.1158/1078-0432.ccr-13-0753.Peer-Reviewed Original ResearchConceptsClinical trialsTumor biologyFuture patient selectionTherapy of patientsOngoing clinical evaluationBroad molecular profilingPromising tumor targetPersonalized medicinePatient selectionPatient populationTreatment recommendationsClinical evaluationTumor boardClinical studiesImmune parametersNovel agentsTumor targetsTreatment approachesSolid tumorsClinical researchPatientsMolecular profilingSpecific markersTumorsTrials
2009
Integration of Molecular Profiling into the Lung Cancer Clinic
Pao W, Kris MG, Iafrate AJ, Ladanyi M, Jänne PA, Wistuba II, Miake-Lye R, Herbst RS, Carbone DP, Johnson BE, Lynch TJ. Integration of Molecular Profiling into the Lung Cancer Clinic. Clinical Cancer Research 2009, 15: 5317-5322. PMID: 19706816, DOI: 10.1158/1078-0432.ccr-09-0913.Peer-Reviewed Original ResearchConceptsMolecular profilingLung cancer clinicThoracic oncology centersMore effective treatmentsMedical oncologyOncology centersAppropriate trialsLung cancerOncology practiceCancer clinicEffective treatmentSide effectsMolecular aberrationsNecessary end pointEnd pointPatientsRoutine partTherapyAppropriate candidatesTrialsRare mutationsAdequate numberStandardized methodMultiple institutionsEarly stages