2019
Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function
Wang SB, Xu T, Peng S, Singh D, Ghiassi-Nejad M, Adelman RA, Rizzolo LJ. Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function. Communications Biology 2019, 2: 113. PMID: 30937396, PMCID: PMC6433901, DOI: 10.1038/s42003-019-0355-0.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumClaudin-19Retinal neurogenesisP1 waveOuter nuclear layerRPE signature genesARPE19 cell lineOcular involvementKidney diseaseVisual functionFamilial hypomagnesaemiaNuclear layerBipolar cellsNewborn miceOcular diseasesPigment epitheliumRetinal isomeraseDiseaseMiceHuman induced pluripotent cellsRetinal differentiationSignature genesCell linesNeurogenesisInduced pluripotent cells
2017
A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells
Singh D, Wang SB, Xia T, Tainsh L, Ghiassi-Nejad M, Xu T, Peng S, Adelman RA, Rizzolo LJ. A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells. Biomaterials 2017, 154: 158-168. PMID: 29128844, DOI: 10.1016/j.biomaterials.2017.10.052.Peer-Reviewed Original ResearchConceptsRetinal degenerationNeurosensory retinaRetinal cellsHost retinal pigment epitheliumStem cellsOuter nuclear layerRetinal pigment epitheliumRetinal cell typesElaborate arborsQuantitative RT-PCRLeading causeImmune responseNuclear layerMouse modelPigment epitheliumSubretinal spaceForebrain cellsMinimal immune responseTherapeutic agentsRetinal laminationRT-PCRDegenerationRetinaRetinal organoidsConfocal immunocytochemistry
2011
Proliferation of the ciliary epithelium with retinal neuronal and photoreceptor cell differentiation in human eyes with retinal detachment and proliferative vitreoretinopathy
Ducournau Y, Boscher C, Adelman RA, Guillaubey C, Schmidt-Morand D, Mosnier JF, Ducournau D. Proliferation of the ciliary epithelium with retinal neuronal and photoreceptor cell differentiation in human eyes with retinal detachment and proliferative vitreoretinopathy. Graefe's Archive For Clinical And Experimental Ophthalmology 2011, 250: 409-423. PMID: 21932075, DOI: 10.1007/s00417-011-1797-3.Peer-Reviewed Original ResearchMeSH KeywordsAC133 AntigenAdultAntigens, CDCell DifferentiationCell MovementCell ProliferationCiliary BodyErbB ReceptorsFemaleGlial Fibrillary Acidic ProteinGlycoproteinsHumansImmunoenzyme TechniquesKi-67 AntigenMaleMiddle AgedParaffin EmbeddingPeptidesPhosphopyruvate HydratasePhotoreceptor Cells, VertebratePigment Epithelium of EyeRetinal DetachmentRetinal NeuronsRhodopsinVitreoretinopathy, ProliferativeConceptsAnterior proliferative vitreoretinopathyRetinal detachmentAdult human eyeProliferative vitreoretinopathyCiliary bodyRetinal progenitor cellsControl eyesAdult ciliary bodyCE cellsMethodsThe present studyHuman eyeRetinal transplantationEndoscopic evaluationGFAP stainingCiliary epithelial cellsPhotoreceptor lineageOrbital tumorsVitreous baseNormal eyesDetached retinaStrong stainingGlial formationCiliary epitheliumConclusionsOur observationsDonor cells