2019
Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions
Alofe O, Kisanga E, Inayat-Hussain SH, Fukumura M, Garcia-Milian R, Perera L, Vasiliou V, Whirledge S. Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions. Environment International 2019, 131: 104969. PMID: 31310931, PMCID: PMC6728168, DOI: 10.1016/j.envint.2019.104969.Peer-Reviewed Original ResearchConceptsEstrogen receptorEstradiol-mediated inductionLow-dose combinationIshikawa cell lineLow-dose effectsDirect stimulatoryPotential of chemicalsRate of proliferationOccupational exposureIshikawa cellsAnimal modelsHuman studiesReproductive toxicityCarcinogenic effectsInhibitory effectToxicology testingEndocrineCell proliferationEndocrine disruption potentialDose effectReceptor interactionIndustrial chemicalsCell linesPublic healthAdditive effect
2018
Prioritization of reproductive toxicants in unconventional oil and gas operations using a multi-country regulatory data-driven hazard assessment
Inayat-Hussain SH, Fukumura M, Aziz A, Jin CM, Jin LW, Garcia-Milian R, Vasiliou V, Deziel NC. Prioritization of reproductive toxicants in unconventional oil and gas operations using a multi-country regulatory data-driven hazard assessment. Environment International 2018, 117: 348-358. PMID: 29793188, DOI: 10.1016/j.envint.2018.05.010.Peer-Reviewed Original ResearchConceptsReproductive toxicantsUOG chemicalsReproductive toxicityStringent classificationAdverse birth outcomesPotential etiologic agentsGerm cell mutagenicityMultiple adverse effectsPotential public health riskBirth outcomesRegulatory agency databasesEpidemiologic studiesEtiologic agentReproductive healthScoring systemPublic health riskSafe alternativeAdverse effectsHazard identificationDevelopmental toxicantsHazard scoreCytoscape analysisExposure assessmentCancerHealth risks