2006
Pacemaker activity in the upper urinary tract
Weiss RM, Tamarkin FJ, Wheeler MA. Pacemaker activity in the upper urinary tract. Journal Of Smooth Muscle Research 2006, 42: 103. PMID: 17099294, DOI: 10.1540/jsmr.42.103.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsTypical smooth muscle cellsMuscle cellsUreteral peristalsisCapsaicin-sensitive sensory afferentsAlpha-smooth muscle actinNormal ureteral peristalsisUpper urinary tractUreteral peristaltic activityUrinary collecting systemTyrosine kinase receptorsSensory afferentsUrinary tractEndogenous releasePeristaltic activityPacemaker activityMuscle actinAction potentialsPacemaker siteC-kitPacemaker cellsProximal portionCollecting systemSparse immunoreactivityElectrical activity
2005
Regulation of cyclic nucleotides in the urinary tract
Wheeler MA, Ayyagari RR, Wheeler GL, Weiss RM. Regulation of cyclic nucleotides in the urinary tract. Journal Of Smooth Muscle Research 2005, 41: 1. PMID: 15855736, DOI: 10.1540/jsmr.41.1.Peer-Reviewed Original ResearchConceptsUrinary tractRelaxation responseLow compliance bladderSmooth muscle functionG proteinsCyclic AMP productionStimulatory G proteinCyclic nucleotide levelsG protein isoformsUrge incontinenceTreatment optionsProstate cancerMuscle functionDisease processFamily of phosphodiesterasesSpecific PDE inhibitorsAMP productionPDE inhibitorsBladderAdenylyl cyclasePDE isoformsTractPharmacological potentialCancerPDE expression
2000
AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. DOI: 10.1016/s0022-5347(05)67319-3.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile responseAGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN
WADA Y, LATIFPOUR J, SANEMATSU H, AFIATPOUR P, WANG Z, SAITO M, NISHI K, WEISS R. AGE-RELATED CHANGES IN CONTRACTILE RESPONSES OF RABBIT LOWER URINARY TRACT TO ENDOTHELIN. Journal Of Urology 2000, 164: 806-813. PMID: 10953160, DOI: 10.1097/00005392-200009010-00054.Peer-Reviewed Original ResearchConceptsRabbit lower urinary tractSmooth muscle layerContractile responseLower urinary tractMonth-old rabbitsBladder domeUrinary tractET receptorsET-1Muscle layerMuscle stripsReceptor antagonistOld rabbitsReceptor subtypesMonths old male rabbitsSelective ETA receptor antagonistSelective ETB receptor antagonistMammalian urinary tractMediation of contractionSignificant contractile responseUrethral muscle stripsMaximal contractile responseET receptor subtypesETA receptor antagonistMaximum contractile responseGene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome
Saito M, Wada Y, Ikeda K, Wang Z, Smith S, Foster H, Nishi K, Weiss R, Latifpour J. Gene expression, localization, and pharmacological characterization of endothelin receptors in diabetic rat bladder dome. European Journal Of Pharmacology 2000, 387: 253-263. PMID: 10650170, DOI: 10.1016/s0014-2999(99)00753-0.Peer-Reviewed Original ResearchConceptsRat bladder domeEndothelin receptorsBladder domeInsulin treatmentReceptor subtypesFunctional endothelin receptorsMammalian urinary tractEndothelin receptor subtypesInduction of diabetesAge-matched controlsReceptor alterationsExperimental diabetesUrinary tractPharmacological characterizationPharmacological profileMuscular layerMRNA upregulationAutoradiographic studyTranscription-polymerase chain reaction dataReceptorsExpression levelsDiabetesTissue componentsSubtypesTreatment
1999
Developmental aspects of endothelin receptors in rabbit lower urinary tract
Saito M, Latifpour J, Weiss R. Developmental aspects of endothelin receptors in rabbit lower urinary tract. Neurourology And Urodynamics 1999, 19: 71-85. PMID: 10602249, DOI: 10.1002/(sici)1520-6777(2000)19:1<71::aid-nau8>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsLower urinary tractRabbit lower urinary tractEndothelin receptorsUrinary tractBladder baseBladder domeMale rabbitsEndothelin receptor subtypesAge-related alterationsOld male rabbitsET receptorsReceptor subtypesPharmacological characterizationPharmacological profileAged rabbitsSubtype specificityReceptorsTractDevelopment-related changesSimilar proportionsWeeksReceptor compoundsUrethraRabbitsRank order
1997
Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle
Wheeler M, Pontari M, Dokita S, Nishimoto T, Cho Y, Hong K, Weiss R. Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle. Molecular And Cellular Biochemistry 1997, 169: 115-124. PMID: 9089638, DOI: 10.1023/a:1006823611864.Peer-Reviewed Original ResearchConceptsSoluble guanylyl cyclase activityAdult guinea pigsGuanylyl cyclase activityCyclase activityBladder domeSodium nitroprussideGuinea pigsUrinary tract smooth muscleGuanylyl cyclaseAtrial natriuretic factorParticulate guanylyl cyclaseAge-dependent changesAge-specific differencesUrinary tractNatriuretic factorSmooth muscleUreterUrethraRelaxation responseBladderInduced activationNitroprussideTissueRank orderAgeEvidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract
Mutoh S, Latifpour J, Saito M, Weiss R. Evidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract. Journal Of Urology 1997, 157: 717-721. PMID: 8996405, DOI: 10.1016/s0022-5347(01)65257-1.Peer-Reviewed Original ResearchConceptsCarbachol-induced contractile responsesBladder baseContractile responseBladder domeMuscarinic antagonistMuscarinic receptorsUrinary tractReceptor subtypesRabbit Lower Urinary TractSubtype-selective muscarinic antagonistsSubtype specificityContractile response curvesM2 receptor subtypeM3 receptor subtypeLower Urinary TractMuscarinic cholinergic receptorsMuscarinic cholinergic antagonistSelective muscarinic antagonistsConcentrations of carbacholTerms of efficacyCholinergic antagonistsCholinergic receptorsPA2 valuesAntagonist affinityUrethraEvidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract
Mutoh S, Latifpour J, Saito M, Weiss R. Evidence for the Presence of Regional Differences in the Subtype Specificity of Muscarinic Receptors in Rabbit Lower Urinary Tract. Journal Of Urology 1997, 157: 717-721.. DOI: 10.1097/00005392-199702000-00095.Peer-Reviewed Original ResearchCarbachol-induced contractile responsesBladder baseContractile responseBladder domeMuscarinic antagonistMuscarinic receptorsUrinary tractReceptor subtypesRabbit Lower Urinary TractSubtype-selective muscarinic antagonistsSubtype specificityContractile response curvesM2 receptor subtypeM3 receptor subtypeLower Urinary TractMuscarinic cholinergic receptorsMuscarinic cholinergic antagonistSelective muscarinic antagonistsConcentrations of carbacholTerms of efficacyCholinergic antagonistsCholinergic receptorsPA2 valuesAntagonist affinityUrethra
1996
Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435. PMID: 8632605, DOI: 10.1016/s0022-5347(01)66301-8.Peer-Reviewed Original ResearchConceptsUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityTract infectionsGMP levelsFemale controlsFemale urinary tract infectionCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseCyclic GMPUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435.. DOI: 10.1097/00005392-199604000-00098.Peer-Reviewed Original ResearchUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityFemale controlsTract infectionsGMP levelsResults Female patientsCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityAbstract PurposeDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclase
1995
Regional differences in the density and subtype specificity of endothelin receptors in rabbit urinary tract
Latifpour J, Fukumoto Y, Weiss R. Regional differences in the density and subtype specificity of endothelin receptors in rabbit urinary tract. Naunyn-Schmiedeberg's Archives Of Pharmacology 1995, 352: 459-468. PMID: 8751073, DOI: 10.1007/bf00169378.Peer-Reviewed Original ResearchConceptsBladder baseSarafotoxin S6cBladder domeUrinary tractETB receptorsET-3Rabbit urinary tractSubtype specificityBQ-123Endothelin receptorsET receptorsReceptor subtypesET-1Human ETASelective ETA receptor antagonistSelective ETB agonistETA receptor antagonistETB receptor subtypesSingle receptor subtypeETA receptorsETB agonistChinese hamster ovary KReceptor antagonistSimilar binding studiesUrethraEffect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract
Wheeler M, Martin T, Weiss R. Effect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract. Journal Of Urology 1995, 153: 2044-2049. PMID: 7752391, DOI: 10.1016/s0022-5347(01)67399-3.Peer-Reviewed Original ResearchConceptsPhosphatidyl inositol hydrolysisPI hydrolysisCyclic AMP levelsCAMP levelsBladder domeAMP levelsUrinary tract functionEffect of carbacholGuinea-pig ureterAgonist-induced changesBasal cAMP levelsUrinary tractMuscarinic cholinergicTract functionSecond messenger systemsCarbacholNorepinephrinePig ureterSustained increaseUreterUrethraSecond messenger levelsMessenger systemsForskolinTransitory increaseEffect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract
Wheeler M, Martin T, Weiss R. Effect of Carbachol and Norepinephrine on Phosphatidyl Inositol Hydrolysis and Cyclic Amp Levels in Guinea Pig Urinary Tract. Journal Of Urology 1995, 153: 2044-2049.. DOI: 10.1097/00005392-199506000-00100.Peer-Reviewed Original ResearchPhosphatidyl inositol hydrolysisPI hydrolysisCyclic AMP levelsCAMP levelsBladder domeAMP levelsUrinary tract functionEffect of carbacholGuinea-pig ureterAgonist-induced changesBasal cAMP levelsUrinary tractMuscarinic cholinergicSecond messenger systemsTract functionCarbacholNorepinephrinePig ureterSustained increaseUreterUrethraSecond messenger levelsMessenger systemsForskolinMessenger levels
1993
Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract
Yoshida M, Latifpour J, Weiss R. Age-related changes in Ca2+ channel antagonist receptors in rabbit lower urinary tract. European Journal Of Pharmacology 1993, 232: 159-167. PMID: 8385616, DOI: 10.1016/0014-2999(93)90769-e.Peer-Reviewed Original ResearchConceptsLower urinary tractBladder baseBladder domeUrinary tractChannel antagonistsRabbit lower urinary tractBay K 8644Channel antagonist receptorsAge-dependent changesDensity of Ca2Age-related changesAntagonist binding sitesReceptor densityPharmacological profileAntagonist receptorsRabbit urethraUrethraAge groupsBmax valuesDays rabbitsAntagonistTractWeeksRank orderBinding sites
1990
Autonomic receptors in urinary tract: sex and age differences.
Latifpour J, Kondo S, O'Hollaren B, Morita T, Weiss R. Autonomic receptors in urinary tract: sex and age differences. Journal Of Pharmacology And Experimental Therapeutics 1990, 253: 661-7. PMID: 2338651.Peer-Reviewed Original ResearchConceptsAlpha-2 adrenergic receptorsBladder domeBladder baseBeta-adrenergic receptorsAdrenergic receptorsCholinergic receptorsMuscarinic receptorsUrinary tractAlpha-2 adrenergic receptor densityLower urinary tract smooth muscleUrinary tract smooth muscleRabbit bladder baseAlpha 2A subtypeMuscarinic cholinergic receptorsAdrenergic receptor densityLower urinary tractSelective adrenergic agonistsAdult rat cortexNeonatal rat lungBeta-2 adrenergic receptorsAutonomic receptorsAge-related differencesRat cortexAdrenergic agonistsMale urethra
1989
Characterization of Autonomic Receptors in Neonatal Urinary Tract Smooth Muscle
Latifpour J, Morita T, O'Hollaren B, Kondo S, Weiss R. Characterization of Autonomic Receptors in Neonatal Urinary Tract Smooth Muscle. Neonatology 1989, 13: 1-10. PMID: 2570683, DOI: 10.1159/000457575.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic AgonistsAnimalsAnimals, NewbornCarbacholClonidineDihydroalprenololDose-Response Relationship, DrugIn Vitro TechniquesMuscle ContractionMuscle, SmoothPrazosinQuinuclidinyl BenzilateRabbitsReceptors, Adrenergic, alphaReceptors, Adrenergic, betaReceptors, MuscarinicUrinary TractYohimbineConceptsUrinary tract smooth muscleSmooth muscleAutonomic receptorsBeta-adrenergic receptor densityAlpha-1 adrenergic receptorsNeonatal urinary tractAlpha 2 receptorsAlpha 1 receptorsAlpha-adrenergic agonistsFunctional muscarinic receptorsRelaxant responsesBladder baseBladder domeMuscarinic receptorsUrinary tractReceptor densityAdult rabbitsAlpha 2ReceptorsMuscleAgonistsRank orderRabbitsHigher numberIsoproterenol
1987
Preliminary Results with Aminophylline as Smooth-Muscle Relaxant in Percutaneous Renal Surgery
GREEN D, GLICKMAN M, WEISS R. Preliminary Results with Aminophylline as Smooth-Muscle Relaxant in Percutaneous Renal Surgery. Journal Of Endourology 1987, 1: 243-247. DOI: 10.1089/end.1987.1.243.Peer-Reviewed Case Reports and Technical NotesUreteropelvic junctionUpper urinary tractSmooth muscle relaxantSmooth muscle relaxationPercutaneous renal surgeryInfundibular spasmUrinary tractRenal surgeryRenal stonesSmooth muscleCaliceal stonesSpasmPhosphodiesterase inhibitorPatientsAminophyllineStrictureStonesRelaxantsSurgeryPyeloplastyScarringEndopyelotomyTractOcclusion
1971
Ipsilateral Ureteroureterostomy in the Management of Vesicoureteral Reflux in Duplication of upper Urinary Tract
Lytton B, Weiss R, Berneike R. Ipsilateral Ureteroureterostomy in the Management of Vesicoureteral Reflux in Duplication of upper Urinary Tract. Journal Of Urology 1971, 105: 507-510. PMID: 5556696, DOI: 10.1016/s0022-5347(17)61560-x.Peer-Reviewed Original Research