2024
Chikungunya Arthritis Treatment with Methotrexate and Dexamethasone: A Randomized, Double-blind, Placebo-controlled Trial
Amaral J, Lucena G, Schoen R. Chikungunya Arthritis Treatment with Methotrexate and Dexamethasone: A Randomized, Double-blind, Placebo-controlled Trial. Current Rheumatology Reviews 2024, 20: 337-346. PMID: 38173199, DOI: 10.2174/0115733971278715231208114037.Peer-Reviewed Original ResearchChronic chikungunya arthritisChikungunya arthritisDouble-blindJoint countPlacebo-controlled clinical trialPain visual analog scalePlacebo-controlled trialChikungunya feverPatient global assessmentVisual analog scaleAffected individualsSwollen joint countTender joint countChikungunya virus infectionDAS28-ESRDexamethasone groupSD ageAnalog scaleBiphasic diseaseTreatment responseClinical trialsAcute phaseDexamethasoneVirus infectionGlobal assessmentBone erosions and joint damage caused by chikungunya virus: a systematic review
Amaral J, Taylor P, Schoen R. Bone erosions and joint damage caused by chikungunya virus: a systematic review. Revista Da Sociedade Brasileira De Medicina Tropical 2024, 57: e00404-2024. PMID: 38597523, PMCID: PMC11000508, DOI: 10.1590/0037-8682-0433-2023.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisChikungunya arthritisJoint damageRheumatoid arthritisJoint painDisease-modifying antirheumatic drug therapyBone erosionProgression of radiographic joint damageDisease-modifying antirheumatic drugsSystematic reviewAntirheumatic drug therapyAcute febrile illnessPersistent joint painSimilar to rheumatoid arthritisRadiographic joint damageChikungunya virusYears post-infectionChronic joint damagePrevent joint damageDisease-modifying therapiesJoint structural damageRheumatoid arthritis treatmentAntirheumatic drugsProspective studyChikungunya infectionQuality of Life and Disability in Chikungunya Arthritis
Amaral J, Taylor P, Weinblatt M, Bandeira Í, Schoen R. Quality of Life and Disability in Chikungunya Arthritis. Current Rheumatology Reviews 2024, 20: 65-71. PMID: 37605393, DOI: 10.2174/1573397119666230726113647.Peer-Reviewed Original ResearchConceptsChikungunya arthritisVisual analog scaleSF-12Quality of lifeChikungunya feverVisual analog scale pain scoreShort Form Health SurveyHealth Assessment Questionnaire Disability IndexRetrospective cross-sectional studyVirus-infected patientsCKV patientsCross-sectional studyPublic health impactChikungunya fever patientsChikungunya virus infectionMCS-12PCS-12Assess disabilityOutbreak of chikungunya feverHealth SurveyDisability IndexPain scoresDAS28-ESRAnalog scaleMosquito vectors
2023
Therapy for Chikungunya Arthritis: A Study of 133 Brazilian Patients.
Amaral J, Bingham C, Taylor P, Vilá L, Weinblatt M, Schoen R. Therapy for Chikungunya Arthritis: A Study of 133 Brazilian Patients. American Journal Of Tropical Medicine And Hygiene 2023, 109: 542-547. PMID: 37549898, PMCID: PMC10484246, DOI: 10.4269/ajtmh.23-0205.Peer-Reviewed Original ResearchConceptsChikungunya arthritisWeeks of treatmentSwollen joint countTender joint countJoint countDAS28-erythrocyte sedimentation rateAge of patientsTreated with methotrexateDisease Activity ScoreGroup of patientsMedical record reviewAcute chikungunyaPain scoresClinical improvementBrazilian patientsAssess painClinical criteriaBaseline visitActivity scoreMaintained 5 monthsPainPatientsRecord reviewSelf-limitingRheumatology practice
2022
Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis
Amaral J, Bingham C, Taylor P, Vilá L, Weinblatt M, Schoen R. Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis. Travel Medicine And Infectious Disease 2022, 52: 102534. PMID: 36549417, DOI: 10.1016/j.tmaid.2022.102534.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisMesenchymal stem cellsJoint painChikungunya virusReactivation of dormant virusesMorphologically similar to fibroblastsChikungunya feverEpigenetic changesChronic joint painAcute febrile illnessChikungunya virus infectionSimilar to fibroblastsMaculopapular rashChikungunya arthritisDormant virusesFebrile illnessLatent infectionMultipotent cellsStem cellsHeterogeneous groupRheumatoid arthritisPathogenic hypothesisGroup of multipotent cellsPainPatientsChikungunya Arthritis
Amaral J, Pal T, Schoen R. Chikungunya Arthritis. Rare Diseases Of The Immune System 2022, 179-190. DOI: 10.1007/978-3-031-05002-2_14.Peer-Reviewed Original ResearchDisease-modifying anti-rheumatic drugsAnti-rheumatic drugsInflammatory rheumatic diseasesChikungunya arthritisChronic arthritisSupportive careBiphasic illnessRheumatic diseasesRheumatoid arthritisInflammatory processViral infectionArthritisAlphavirus infectionMillions of peopleIllnessInfectionDiseaseChikungunyaSubtropical worldArthralgiaRashPatientsFeverMethotrexateCare