2014
Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain
Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain 2014, 137: 1039-1050. PMID: 24549959, PMCID: PMC3959553, DOI: 10.1093/brain/awu007.Peer-Reviewed Original ResearchConceptsContact hypersensitivityPruriceptive neuronsEnhanced excitabilityNervous systemNociceptive dorsal root ganglion (DRG) neuronsSodium currentVehicle-treated control animalsDorsal root ganglion neuronsSquaric acid dibutyl esterItch-like behaviorsPain-related behaviorsResistant sodium currentsAllergic contact dermatitisAction potential activityWhole-cell recordingsInflammatory itchPersistent itchPruritic disordersSpontaneous itchSpontaneous scratchingAcute itchNeuronal hyperexcitabilityNociceptive neuronsPruritic diseasesCommon symptoms
2012
A subpopulation of nociceptors specifically linked to itch
Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 2012, 16: 174-182. PMID: 23263443, PMCID: PMC3557753, DOI: 10.1038/nn.3289.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAntirheumatic AgentsCalciumCapsaicinCells, CulturedChloroquineEpidermisGanglia, SpinalGene Expression RegulationGreen Fluorescent ProteinsHistamineHot TemperatureMaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityNerve FibersNerve Tissue ProteinsNociceptorsPain MeasurementPain ThresholdPatch-Clamp TechniquesPeptide FragmentsPlant LectinsProteinsProto-Oncogene Proteins c-fosPruritusReceptors, BombesinReceptors, G-Protein-CoupledRNA, UntranslatedRotarod Performance TestSensory Receptor CellsSensory System AgentsSpinal CordTRPV Cation Channels