1997
An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion
Zhang J, Song X, LaMotte R. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain 1997, 72: 51-57. PMID: 9272787, DOI: 10.1016/s0304-3959(97)00013-4.Peer-Reviewed Original ResearchConceptsDorsal root gangliaNerve-injured ratsAdrenergic sensitivitySpontaneous activityUninjured nerveDRG cellsRoot gangliaSciatic nerveL5 dorsal root gangliaIntact dorsal root gangliaSelective alpha2-adrenergic agonistRat dorsal root gangliaAbnormal spontaneous activityInjured DRG neuronsSympathetic nervous systemAlpha2-adrenergic agonistDorsal root fibersIntact blood circulationCutaneous hyperalgesiaSpontaneous painDRG neuronsDorsal rootsSpontaneous dischargeC-fibersPeripheral axons
1995
Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat
Xie Y, Zhang J, Petersen M, LaMotte R. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat. Journal Of Neurophysiology 1995, 73: 1811-1820. PMID: 7623082, DOI: 10.1152/jn.1995.73.5.1811.Peer-Reviewed Original ResearchConceptsDorsal root gangliaChronic nerve constrictionMost C-fibersC-fibersNerve constrictionSpontaneous activityInjury siteDRG somataDorsal rootsDorsal root ganglion cellsNerve-injured ratsIpsilateral sciatic nerveL5 dorsal rootAlpha 2 receptorsEffects of norepinephrineDorsal root fibersThermal stimuliUninjured neuronsUninjured ratsNerve injurySympathetic trunkUninjured nerveSympathetic stimulationCutaneous painExcitatory responses
1992
Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.
Torebjörk H, Lundberg L, LaMotte R. Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans. The Journal Of Physiology 1992, 448: 765-780. PMID: 1593489, PMCID: PMC1176227, DOI: 10.1113/jphysiol.1992.sp019069.Peer-Reviewed Original ResearchConceptsMechanical hyperalgesiaCapsaicin injectionIntraneural microstimulationMechanoreceptive inputCapsaicin-induced secondary hyperalgesiaCutaneous innervation territoryArea of hyperalgesiaHealthy human subjectsSecondary hyperalgesiaAlgesic substancesLidocaine anesthesiaInnervation territoryIntense painIntradermal injectionUnmyelinated fibersHyperalgesiaMyelinated fibersC-fibersCentral changesPainAfferent signalsImpulse conductionSuprathreshold stimulationSkin areasTactile sensation