2015
Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis
Pall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis. Journal Of Pain 2015, 16: 741-749. PMID: 26002605, PMCID: PMC4522332, DOI: 10.1016/j.jpain.2015.04.009.Peer-Reviewed Original ResearchConceptsSquaric acid dibutyl esterAllergic contact dermatitisSpontaneous itchContact dermatitisNociceptive sensationsT cell-mediated inflammationExperimental modelPeripheral neural activityQuality of lifeInflammatory itchBAM8-22Skin inflammationHypersensitivity reactionsPain sensationAllergen resultsIntradermal injectionCommon conditionHealthy volunteersPotential treatmentItchPsychophysical measurementsInflammationVolar forearmDermatitisNeural activity
1999
Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia
Atanassoff P, Brull S, Zhang J, Greenquist K, Silverman D, Lamotte R. Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosensory & Motor Research 1999, 16: 291-298. PMID: 10632026, DOI: 10.1080/08990229970357.Peer-Reviewed Original ResearchConceptsAreas of dysesthesiaDuration of itchHistamine-evoked itchPrimary afferent neuronsAbnormal sensationAfferent neuronsCutaneous areaCentral inhibitionLocal anesthesiaEnhanced painControl armIntradermal injectionLocal anestheticsExperimental pruritusPainItchVolar forearmHistamineMechanical stimulationAfferentsHuman subjectsAnestheticsSkinPresent studySensation
1991
Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine
Simone D, Alreja M, Lamotte R. Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine. Somatosensory & Motor Research 1991, 8: 271-279. PMID: 1767623, DOI: 10.3109/08990229109144750.Peer-Reviewed Original ResearchConceptsDuration of itchSubcutaneous injectionIntracutaneous injectionItchy skinArea of alloknesisSensation of itchMicrograms of histamineSkin temperatureItch sensationLocal anesthesiaAlloknesisMean latencyInjection siteMean maximum areaItchHuman volunteersHistamineVolar forearmDose-response functionInjectionNeural mechanismsSkinDoseDurationMicrograms
1987
The Magnitude and Duration of Itch Produced by Intracutaneous Injections of Histamine
Simone D, Ngeow J, Whitehouse J, Becerra-Cabal L, Putterman G, Lamotte R. The Magnitude and Duration of Itch Produced by Intracutaneous Injections of Histamine. Somatosensory & Motor Research 1987, 5: 81-92. PMID: 3423533, DOI: 10.3109/07367228709144620.Peer-Reviewed Original ResearchConceptsDuration of itchArea of flareIntracutaneous injectionDose-dependent fashionHistamine doseMicrograms of histaminePeripheral neural mechanismsDose-dependent mannerIntracutaneous histamineItch magnitudeItch sensationLow doseItchHistamineVolar forearmDoseNeurophysiological studiesLonger durationMicrogramsMultiple injectionsInjectionNeural mechanismsDurationWeeksSubjects