2016
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Advances In Experimental Medicine And Biology 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPersistent itchPathogenesis of ACDSquaric acid dibutyl esterPain-like behaviorsSmall-diameter neuronsPeripheral neural mechanismsPossible therapeutic targetInflammatory itchPruritic disordersCutaneous sitesChemokine CXCL10Excitatory responsesLocal inflammationReceptor CXCR3Contact dermatitisUnmyelinated axonsSpontaneous activityTherapeutic targetAnimal modelsPainSubsequent challengeTopical applicationItchMice
1997
Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated Axons
Zhang J, Donnelly D, Song X, Lamotte R. Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated Axons. Journal Of Neurophysiology 1997, 78: 2790-2794. PMID: 9356426, DOI: 10.1152/jn.1997.78.5.2790.Peer-Reviewed Original ResearchConceptsDorsal root gangliaUnmyelinated axonsRoot gangliaSodium currentTTX-sensitive sodium currentWhole-cell patch-clamp recordingsCell patch-clamp recordingsDorsal root ganglion cellsTTX-resistant currentC cellsEffects of axotomyAction potential thresholdPatch-clamp recordingsAction potential durationNeuropathic painVoltage-clamp conditionsPeak sodium currentDRG cellsGanglion cellsSoma sizeFast BlueNerve fibersConduction velocityAxotomyPotential duration
1996
Chapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat
LaMotte R, Zhang J, Petersen M. Chapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat. Progress In Brain Research 1996, 110: 105-111. PMID: 9000719, DOI: 10.1016/s0079-6123(08)62568-6.Peer-Reviewed Original ResearchConceptsDorsal root gangliaSensory neuronsIntact neuronsPartial peripheral nerve injuryDorsal root ganglion cellsChronic nerve constrictionPeripheral axonal injuryPeripheral nerve injuryPeripheral sensory neuronsPrimary sensory neuronsNerve constrictionNerve injuryAbnormal responsivenessAxonal injuryCollateral sproutingNeuropathological changesNociceptive activityDRG cellsRoot gangliaGanglion cellsSame nerveInjury siteUnmyelinated axonsAxonsNeurons