2024
Itch and Pain Behaviors in Irritant Contact Dermatitis Produced by Sodium Lauryl Sulfate in Mice
Malewicz-Oeck N, Zhang Z, Shimada S, LaMotte R. Itch and Pain Behaviors in Irritant Contact Dermatitis Produced by Sodium Lauryl Sulfate in Mice. International Journal Of Molecular Sciences 2024, 25: 7718. PMID: 39062959, PMCID: PMC11276812, DOI: 10.3390/ijms25147718.Peer-Reviewed Original ResearchIrritant contact dermatitisDay 1Heat stimuliSkin inflammationSigns of spontaneous painContact dermatitisHyperalgesia-like behaviorResponses to pruritogensPain-like behaviorsSodium lauryl sulfateCompared to salineMeasurement of skin thicknessSpontaneous painIncreased skin thicknessHistamine-dependentPain behaviorCutaneous inflammationScratching boutsMouse modelPainSkin thicknessItchingInflammationMiceDay 0
1997
An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion
Zhang J, Song X, LaMotte R. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain 1997, 72: 51-57. PMID: 9272787, DOI: 10.1016/s0304-3959(97)00013-4.Peer-Reviewed Original ResearchConceptsDorsal root gangliaNerve-injured ratsAdrenergic sensitivitySpontaneous activityUninjured nerveDRG cellsRoot gangliaSciatic nerveL5 dorsal root gangliaIntact dorsal root gangliaSelective alpha2-adrenergic agonistRat dorsal root gangliaAbnormal spontaneous activityInjured DRG neuronsSympathetic nervous systemAlpha2-adrenergic agonistDorsal root fibersIntact blood circulationCutaneous hyperalgesiaSpontaneous painDRG neuronsDorsal rootsSpontaneous dischargeC-fibersPeripheral axons