1996
Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy Volunteers
Lundell J, Silverman D, Brull S, O'Connor T, Kitahata L, Collins J, LaMotte R. Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy Volunteers. Anesthesiology 1996, 84: 502-509. PMID: 8659776, DOI: 10.1097/00000542-199603000-00003.Peer-Reviewed Original ResearchConceptsHealthy volunteersEffect of pretreatmentNonsteroidal antiinflammatory drugsSystemic side effectsBradykinin-induced hyperalgesiaContact thermal stimulatorRepeated-measures analysisInflammatory painBradykinin injectionPain intensityPain thresholdAntiinflammatory drugsLocal injectionHyperalgesiaSide effectsKetorolacDrug AdministrationPainMild burnsThermal stimuliThermal stimulatorInjurySelective effectInjectionSaline
1992
Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
LaMotte R, Lundberg L, Torebjörk H. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. The Journal Of Physiology 1992, 448: 749-764. PMID: 1593488, PMCID: PMC1176226, DOI: 10.1113/jphysiol.1992.sp019068.Peer-Reviewed Original ResearchConceptsDuration of painMagnitude of painC-nociceptorsCapsaicin injectionMechanical hyperalgesiaIntradermal injectionTopical applicationReceptive fieldsC-mechanoheat nociceptorsEffects of capsaicinMean discharge rateCutaneous hyperalgesiaHyperalgesic areaUnchanged responsivenessBackground painAlgesic substancesPeroneal nerveNociceptor excitabilityNociceptor responsesPain thresholdMechanical stimuliNociceptor dischargeIntense painConcomitant painAwake humans
1987
Hyperalgesia to heat after intradermal injection of capsaicin
Simone D, Ngeow J, Putterman G, LaMotte R. Hyperalgesia to heat after intradermal injection of capsaicin. Brain Research 1987, 418: 201-203. PMID: 3664271, DOI: 10.1016/0006-8993(87)90982-6.Peer-Reviewed Original Research
1984
Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers
Torebjörk H, LaMotte R, Robinson C. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers. Journal Of Neurophysiology 1984, 51: 325-339. PMID: 6707724, DOI: 10.1152/jn.1984.51.2.325.Peer-Reviewed Original ResearchConceptsConditioning stimulusIntensity-response functionsNormal skinMost subjectsC-mechanoheat nociceptorsPeripheral neural correlateHeat pain sensationMild heat injuryMagnitude ratingsReceptive fieldsHeat injurySupra-threshold stimuliShort-duration stimuliPain thresholdCutaneous painHeat painPain sensationC-fibersPainNociceptorsHairy skinUninjured skinHeat stimulationMagnitude of responseNeuronal correlatesThe Role of C-Nociceptors in Cutaneous Heat Pain and Hyperalgesia
Lamotte R. The Role of C-Nociceptors in Cutaneous Heat Pain and Hyperalgesia. Ettore Majorana International Science Series 1984, 363-377. DOI: 10.1007/978-1-4613-2807-0_26.Peer-Reviewed Original ResearchCutaneous heat painHeat painCutaneous nociceptorsHeat pain thresholdNoxious heat stimuliSensation of painPeripheral neural mechanismsHeat injuryC-nociceptorsNociceptor responsesPain thresholdAfferent fibersCutaneous receptorsPainCutaneous injuryHeat stimuliHyperalgesiaNociceptorsNeurophysiological studiesInjuryNeural mechanismsMagnitude ratingsPsychophysical studiesStimuliStudy