1999
Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia
Song X, Hu S, Greenquist K, Zhang J, LaMotte R. Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia. Journal Of Neurophysiology 1999, 82: 3347-3358. PMID: 10601466, DOI: 10.1152/jn.1999.82.6.3347.Peer-Reviewed Original ResearchConceptsDorsal root gangliaChronic compressionAcute injuryRoot gangliaPreoperative valuesPostoperative testingFoot withdrawalSpontaneous dischargeIntact sympathetic nervous systemUnmyelinated peripheral nerve fibersEctopic neuronal dischargesEctopic spontaneous dischargesSympathetic nervous systemLow back painPeripheral nerve fibersDorsal root fibersBlood-borne chemicalsExtracellular electrophysiological recordingsActive myelinated fibersCotton wispNonsurgical ratsMechanical hyperalgesiaEctopic dischargesThermal hyperalgesiaBack pain
1992
Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.
Torebjörk H, Lundberg L, LaMotte R. Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans. The Journal Of Physiology 1992, 448: 765-780. PMID: 1593489, PMCID: PMC1176227, DOI: 10.1113/jphysiol.1992.sp019069.Peer-Reviewed Original ResearchConceptsMechanical hyperalgesiaCapsaicin injectionIntraneural microstimulationMechanoreceptive inputCapsaicin-induced secondary hyperalgesiaCutaneous innervation territoryArea of hyperalgesiaHealthy human subjectsSecondary hyperalgesiaAlgesic substancesLidocaine anesthesiaInnervation territoryIntense painIntradermal injectionUnmyelinated fibersHyperalgesiaMyelinated fibersC-fibersCentral changesPainAfferent signalsImpulse conductionSuprathreshold stimulationSkin areasTactile sensationPain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
LaMotte R, Lundberg L, Torebjörk H. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. The Journal Of Physiology 1992, 448: 749-764. PMID: 1593488, PMCID: PMC1176226, DOI: 10.1113/jphysiol.1992.sp019068.Peer-Reviewed Original ResearchConceptsDuration of painMagnitude of painC-nociceptorsCapsaicin injectionMechanical hyperalgesiaIntradermal injectionTopical applicationReceptive fieldsC-mechanoheat nociceptorsEffects of capsaicinMean discharge rateCutaneous hyperalgesiaHyperalgesic areaUnchanged responsivenessBackground painAlgesic substancesPeroneal nerveNociceptor excitabilityNociceptor responsesPain thresholdMechanical stimuliNociceptor dischargeIntense painConcomitant painAwake humans
1991
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.Peer-Reviewed Original ResearchConceptsInjection of capsaicinMechanical hyperalgesiaNerve fibersInjection siteAlgesic substancesPrimary afferent nerve fibersArea of tendernessCapsaicin injection siteMicrograms of capsaicinNociceptive nerve fibersPeripheral neural activityArea of hyperalgesiaCutaneous nerve fibersAfferent nerve fibersMagnitude of painSingle intradermal injectionNeural activityArea of analgesiaSite of injuryLarger mean areaAnesthetized skinNeurogenic hyperalgesiaCutaneous anesthesiaIntradermal injectionPainful stimuli
1989
Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin
Simone D, Baumann T, Collins J, LaMotte R. Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin. Brain Research 1989, 486: 185-189. PMID: 2720428, DOI: 10.1016/0006-8993(89)91293-6.Peer-Reviewed Original Research