2018
Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice
Wang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C, LaMotte RH. Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. Neuroscience Letters 2018, 668: 154-158. PMID: 29355697, PMCID: PMC5829013, DOI: 10.1016/j.neulet.2018.01.031.Peer-Reviewed Original ResearchConceptsDorsal root gangliaBehavioral hypersensitivityNeuronal hyperexcitabilityRoot gangliaCompressed dorsal root ganglionNormal nociceptive responsesAnti-nociceptive effectsChronic neuropathic painPostoperative pain managementCentral nervous systemIntact DRGsL4 DRGChronic compressionIpsilateral pawNeuropathic painRadicular painHind pawsPain managementIpsilateral hindNociceptive informationNociceptive responsesPain behaviorIntervertebral foramenNociceptive stimuliLocal anesthetics
1999
Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia
Atanassoff P, Brull S, Zhang J, Greenquist K, Silverman D, Lamotte R. Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosensory & Motor Research 1999, 16: 291-298. PMID: 10632026, DOI: 10.1080/08990229970357.Peer-Reviewed Original ResearchConceptsAreas of dysesthesiaDuration of itchHistamine-evoked itchPrimary afferent neuronsAbnormal sensationAfferent neuronsCutaneous areaCentral inhibitionLocal anesthesiaEnhanced painControl armIntradermal injectionLocal anestheticsExperimental pruritusPainItchVolar forearmHistamineMechanical stimulationAfferentsHuman subjectsAnestheticsSkinPresent studySensation