Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.Peer-Reviewed Original ResearchConceptsInjection of capsaicinMechanical hyperalgesiaNerve fibersInjection siteAlgesic substancesPrimary afferent nerve fibersArea of tendernessCapsaicin injection siteMicrograms of capsaicinNociceptive nerve fibersPeripheral neural activityArea of hyperalgesiaCutaneous nerve fibersAfferent nerve fibersMagnitude of painSingle intradermal injectionNeural activityArea of analgesiaSite of injuryLarger mean areaAnesthetized skinNeurogenic hyperalgesiaCutaneous anesthesiaIntradermal injectionPainful stimuliNeurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia
Baumann T, Simone D, Shain C, LaMotte R. Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. Journal Of Neurophysiology 1991, 66: 212-227. PMID: 1919668, DOI: 10.1152/jn.1991.66.1.212.Peer-Reviewed Original ResearchConceptsAfferent fibersNeurogenic hyperalgesiaPrimary hyperalgesiaNociceptive fibersPrimary afferentsIntradermal injectionHeat stimuliInjection siteReceptive fieldsCutaneous primary afferent fibersCapsaicin injection siteCutaneous afferent fibersNociceptive afferent fibersInjection of capsaicinCapsaicin-induced painPrimary afferent fibersPeripheral nervous systemPeripheral neural mechanismsArea of skinCapsaicin painSecondary hyperalgesiaDepressed responsivenessCapsaicin injectionIntense painHyperalgesiaNeurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons
Simone D, Sorkin L, Oh U, Chung J, Owens C, LaMotte R, Willis W. Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons. Journal Of Neurophysiology 1991, 66: 228-246. PMID: 1919669, DOI: 10.1152/jn.1991.66.1.228.Peer-Reviewed Original ResearchConceptsSpinothalamic tract neuronsSTT neuronsWDR neuronsInjection siteHT neuronsNeurogenic hyperalgesiaTract neuronsIntradermal injectionPunctate stimuliCapsaicin injection siteMicrograms of capsaicinInjection of capsaicinCutaneous mechanical stimulationInjection of vehicleCentral neural correlatesSuprathreshold heat stimuliCutaneous hyperalgesiaWDR cellsCapsaicin injectionHeat painHyperalgesiaPainAnesthetized monkeysPreinjection valuesHeat stimuli