2024
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte R. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. 2024, 23-32. DOI: 10.1007/978-981-99-8921-8_2.Peer-Reviewed Original ResearchSquaric acid dibutyl esterAllergic contact dermatitisPersistent itchingPathogenesis of allergic contact dermatitisPain-like behaviorsMechanically evoked itchMechanisms of itchPeripheral neural mechanismsClinically significant problemReceptor CXCR3Excitatory responsesIP-10Chemokine CXCL10In vivo recordingsCutaneous sitesLocal inflammationSpontaneous activityPruritic disordersAnimal modelsPainTopical applicationItchingItch disordersMiceTherapeutic target
2016
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Advances In Experimental Medicine And Biology 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPersistent itchPathogenesis of ACDSquaric acid dibutyl esterPain-like behaviorsSmall-diameter neuronsPeripheral neural mechanismsPossible therapeutic targetInflammatory itchPruritic disordersCutaneous sitesChemokine CXCL10Excitatory responsesLocal inflammationReceptor CXCR3Contact dermatitisUnmyelinated axonsSpontaneous activityTherapeutic targetAnimal modelsPainSubsequent challengeTopical applicationItchMice
1995
Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat
Xie Y, Zhang J, Petersen M, LaMotte R. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat. Journal Of Neurophysiology 1995, 73: 1811-1820. PMID: 7623082, DOI: 10.1152/jn.1995.73.5.1811.Peer-Reviewed Original ResearchConceptsDorsal root gangliaChronic nerve constrictionMost C-fibersC-fibersNerve constrictionSpontaneous activityInjury siteDRG somataDorsal rootsDorsal root ganglion cellsNerve-injured ratsIpsilateral sciatic nerveL5 dorsal rootAlpha 2 receptorsEffects of norepinephrineDorsal root fibersThermal stimuliUninjured neuronsUninjured ratsNerve injurySympathetic trunkUninjured nerveSympathetic stimulationCutaneous painExcitatory responses