1999
Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion
Zhang J, Song X, LaMotte R. Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion. Journal Of Neurophysiology 1999, 82: 3359-3366. PMID: 10601467, DOI: 10.1152/jn.1999.82.6.3359.Peer-Reviewed Original ResearchConceptsDorsal root gangliaControl ratsCutaneous hyperalgesiaDRG cellsRoot gangliaSpontaneous activityChronic mechanical compressionCCD cellsAction potential thresholdDRG somataChronic compressionChronic painContralateral footSham operationElectrophysiological changesSpinal injuryIntracellular recordingsPunctate stimulationSensory pathologySensory neuronsIntervertebral foraminaIntrinsic alterationsElectrophysiological propertiesPlantar surfaceHyperalgesia
1998
Patch clamp recording from the intact dorsal root ganglion
Zhang J, Donnelly D, LaMotte R. Patch clamp recording from the intact dorsal root ganglion. Journal Of Neuroscience Methods 1998, 79: 97-103. PMID: 9531465, DOI: 10.1016/s0165-0270(97)00164-7.Peer-Reviewed Original ResearchConceptsPatch-clamp recordingsConduction velocityAction potentialsSciatic nerveC cellsIntact dorsal root gangliaDorsal root ganglion cellsDorsal root gangliaAxonal conduction velocityGanglion sheathL5 DRGDRG cellsRoot gangliaGanglion cellsAP thresholdBeta cellsClamp recordingsSodium currentAdeltaCurrent clampConnective tissueVoltage clampNerveGangliaTTX
1997
Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated Axons
Zhang J, Donnelly D, Song X, Lamotte R. Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated Axons. Journal Of Neurophysiology 1997, 78: 2790-2794. PMID: 9356426, DOI: 10.1152/jn.1997.78.5.2790.Peer-Reviewed Original ResearchConceptsDorsal root gangliaUnmyelinated axonsRoot gangliaSodium currentTTX-sensitive sodium currentWhole-cell patch-clamp recordingsCell patch-clamp recordingsDorsal root ganglion cellsTTX-resistant currentC cellsEffects of axotomyAction potential thresholdPatch-clamp recordingsAction potential durationNeuropathic painVoltage-clamp conditionsPeak sodium currentDRG cellsGanglion cellsSoma sizeFast BlueNerve fibersConduction velocityAxotomyPotential durationAn in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion
Zhang J, Song X, LaMotte R. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain 1997, 72: 51-57. PMID: 9272787, DOI: 10.1016/s0304-3959(97)00013-4.Peer-Reviewed Original ResearchConceptsDorsal root gangliaNerve-injured ratsAdrenergic sensitivitySpontaneous activityUninjured nerveDRG cellsRoot gangliaSciatic nerveL5 dorsal root gangliaIntact dorsal root gangliaSelective alpha2-adrenergic agonistRat dorsal root gangliaAbnormal spontaneous activityInjured DRG neuronsSympathetic nervous systemAlpha2-adrenergic agonistDorsal root fibersIntact blood circulationCutaneous hyperalgesiaSpontaneous painDRG neuronsDorsal rootsSpontaneous dischargeC-fibersPeripheral axons
1996
Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction
Petersen M, Zhang J, Zhang J, LaMotte R. Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction. Pain 1996, 67: 391-397. PMID: 8951934, DOI: 10.1016/0304-3959(96)03146-6.Peer-Reviewed Original ResearchConceptsDorsal root ganglion cellsUninjured nerveGanglion cellsSpontaneous activityWhole-cell patch-clamp recordingsAbnormal spontaneous activityChronic nerve constrictionPeripheral nerve injuryPrimary sensory neuronsPatch-clamp recordingsMedium-sized cellsNerve constrictionTight ligationNerve injuryDRG cellsSciatic nerveNormal nervesAdult ratsSensory neuronsNerveNorepinephrineLow dosesAction potentialsCultures 11Current clampChapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat
LaMotte R, Zhang J, Petersen M. Chapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat. Progress In Brain Research 1996, 110: 105-111. PMID: 9000719, DOI: 10.1016/s0079-6123(08)62568-6.Peer-Reviewed Original ResearchConceptsDorsal root gangliaSensory neuronsIntact neuronsPartial peripheral nerve injuryDorsal root ganglion cellsChronic nerve constrictionPeripheral axonal injuryPeripheral nerve injuryPeripheral sensory neuronsPrimary sensory neuronsNerve constrictionNerve injuryAbnormal responsivenessAxonal injuryCollateral sproutingNeuropathological changesNociceptive activityDRG cellsRoot gangliaGanglion cellsSame nerveInjury siteUnmyelinated axonsAxonsNeurons
1993
Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells
Petersen M, LaMotte R. Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 1993, 54: 37-42. PMID: 7690929, DOI: 10.1016/0304-3959(93)90097-9.Peer-Reviewed Original ResearchConceptsInward currentsDorsal root ganglion neuronsDorsal root ganglion cellsCapsaicin-evoked currentsWhole-cell voltage-clamp conditionsImportant modulatory roleVoltage-clamp conditionsDRG cellsGanglion neuronsGanglion cellsSensory neuronsModulatory roleCapsaicinProgressive decreaseNeuronsCellsExtracellular medium