2006
Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons
Tan Z, Donnelly D, LaMotte R. Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons. Journal Of Neurophysiology 2006, 95: 1115-1123. PMID: 16424456, DOI: 10.1152/jn.00830.2005.Peer-Reviewed Original ResearchConceptsDorsal root gangliaCCD neuronsRoot gangliaChronic compressionTTX-sensitiveL5 dorsal root gangliaWhole-cell patch-clamp recordingsCell patch-clamp recordingsCutaneous afferent neuronsEnhanced neuronal excitabilityTTX-resistant currentSteady-state activation curvePatch-clamp recordingsCutaneous hyperalgesiaCutaneous neuronsDRG somataAfferent neuronsControl neuronsControl ratsNeuronal somataNeuronal excitabilityAdult ratsSpontaneous activityIntervertebral foraminaLower rheobase
1999
Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion
Zhang J, Song X, LaMotte R. Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion. Journal Of Neurophysiology 1999, 82: 3359-3366. PMID: 10601467, DOI: 10.1152/jn.1999.82.6.3359.Peer-Reviewed Original ResearchConceptsDorsal root gangliaControl ratsCutaneous hyperalgesiaDRG cellsRoot gangliaSpontaneous activityChronic mechanical compressionCCD cellsAction potential thresholdDRG somataChronic compressionChronic painContralateral footSham operationElectrophysiological changesSpinal injuryIntracellular recordingsPunctate stimulationSensory pathologySensory neuronsIntervertebral foraminaIntrinsic alterationsElectrophysiological propertiesPlantar surfaceHyperalgesiaAttenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia
Brull S, Atanassoff P, Silverman D, Zhang J, Lamotte R. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosensory & Motor Research 1999, 16: 299-303. PMID: 10632027, DOI: 10.1080/08990229970366.Peer-Reviewed Original ResearchConceptsIntradermal injectionTactile allodyniaNociceptive primary afferent neuronsArea of allodyniaAreas of whealCapsaicin-induced allodyniaPrimary afferent neuronsCutaneous hyperalgesiaCutaneous allodyniaAfferent neuronsExperimental armControl armAllodyniaExperimental pruritusDysesthesiaeOpposite forearmVolar surfaceAlloknesisHuman volunteersItchHistamineHyperknesisHyperalgesiaInhibitory processesWheal
1997
An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion
Zhang J, Song X, LaMotte R. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain 1997, 72: 51-57. PMID: 9272787, DOI: 10.1016/s0304-3959(97)00013-4.Peer-Reviewed Original ResearchConceptsDorsal root gangliaNerve-injured ratsAdrenergic sensitivitySpontaneous activityUninjured nerveDRG cellsRoot gangliaSciatic nerveL5 dorsal root gangliaIntact dorsal root gangliaSelective alpha2-adrenergic agonistRat dorsal root gangliaAbnormal spontaneous activityInjured DRG neuronsSympathetic nervous systemAlpha2-adrenergic agonistDorsal root fibersIntact blood circulationCutaneous hyperalgesiaSpontaneous painDRG neuronsDorsal rootsSpontaneous dischargeC-fibersPeripheral axons
1992
Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
LaMotte R, Lundberg L, Torebjörk H. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. The Journal Of Physiology 1992, 448: 749-764. PMID: 1593488, PMCID: PMC1176226, DOI: 10.1113/jphysiol.1992.sp019068.Peer-Reviewed Original ResearchConceptsDuration of painMagnitude of painC-nociceptorsCapsaicin injectionMechanical hyperalgesiaIntradermal injectionTopical applicationReceptive fieldsC-mechanoheat nociceptorsEffects of capsaicinMean discharge rateCutaneous hyperalgesiaHyperalgesic areaUnchanged responsivenessBackground painAlgesic substancesPeroneal nerveNociceptor excitabilityNociceptor responsesPain thresholdMechanical stimuliNociceptor dischargeIntense painConcomitant painAwake humans
1991
Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons
Simone D, Sorkin L, Oh U, Chung J, Owens C, LaMotte R, Willis W. Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons. Journal Of Neurophysiology 1991, 66: 228-246. PMID: 1919669, DOI: 10.1152/jn.1991.66.1.228.Peer-Reviewed Original ResearchConceptsSpinothalamic tract neuronsSTT neuronsWDR neuronsInjection siteHT neuronsNeurogenic hyperalgesiaTract neuronsIntradermal injectionPunctate stimuliCapsaicin injection siteMicrograms of capsaicinInjection of capsaicinCutaneous mechanical stimulationInjection of vehicleCentral neural correlatesSuprathreshold heat stimuliCutaneous hyperalgesiaWDR cellsCapsaicin injectionHeat painHyperalgesiaPainAnesthetized monkeysPreinjection valuesHeat stimuli
1982
Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat
LaMotte R, Thalhammer J, Torebjörk H, Robinson C. Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. Journal Of Neuroscience 1982, 2: 765-781. PMID: 7086482, PMCID: PMC6564351, DOI: 10.1523/jneurosci.02-06-00765.1982.Peer-Reviewed Original ResearchConceptsConditioning stimulusCutaneous hyperalgesiaMild injuryDevelopment of hyperalgesiaHeat injuryMagnitude of hyperalgesiaMild heat injurySingle conditioning stimulusMagnitude of sensitizationPeripheral neural mechanismsReceptive fieldsPeroneal nervePeripheral determinantsCutaneous receptorsC-fibersAwake humansConduction blockAnesthetized monkeysHyperalgesiaNociceptorsPainGlabrous skinNormal skinInjuryHeat stimulation