2006
Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons
Tan Z, Donnelly D, LaMotte R. Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons. Journal Of Neurophysiology 2006, 95: 1115-1123. PMID: 16424456, DOI: 10.1152/jn.00830.2005.Peer-Reviewed Original ResearchConceptsDorsal root gangliaCCD neuronsRoot gangliaChronic compressionTTX-sensitiveL5 dorsal root gangliaWhole-cell patch-clamp recordingsCell patch-clamp recordingsCutaneous afferent neuronsEnhanced neuronal excitabilityTTX-resistant currentSteady-state activation curvePatch-clamp recordingsCutaneous hyperalgesiaCutaneous neuronsDRG somataAfferent neuronsControl neuronsControl ratsNeuronal somataNeuronal excitabilityAdult ratsSpontaneous activityIntervertebral foraminaLower rheobase
1999
Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion
Zhang J, Song X, LaMotte R. Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion. Journal Of Neurophysiology 1999, 82: 3359-3366. PMID: 10601467, DOI: 10.1152/jn.1999.82.6.3359.Peer-Reviewed Original ResearchConceptsDorsal root gangliaControl ratsCutaneous hyperalgesiaDRG cellsRoot gangliaSpontaneous activityChronic mechanical compressionCCD cellsAction potential thresholdDRG somataChronic compressionChronic painContralateral footSham operationElectrophysiological changesSpinal injuryIntracellular recordingsPunctate stimulationSensory pathologySensory neuronsIntervertebral foraminaIntrinsic alterationsElectrophysiological propertiesPlantar surfaceHyperalgesia