2015
Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice
Wang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH. Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice. PLOS ONE 2015, 10: e0137512. PMID: 26356638, PMCID: PMC4565551, DOI: 10.1371/journal.pone.0137512.Peer-Reviewed Original ResearchConceptsDorsal root gangliaPunctate mechanical stimuliSpontaneous activityChronic compressionCutaneous nociceptorsL3 dorsal root gangliaPost-operative day 2Evoked pain behaviorsPain-like behaviorsVon Frey filamentsDorsum of footUnoperated control miceMechanical stimuliCutaneous C nociceptorsBehavioral hyperalgesiaCCD surgeryIntraforaminal stenosisMechanical allodyniaRadicular painC-nociceptorsDRG neuronsPain behaviorControl miceEnhanced excitabilityControl neurons
2006
Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons
Tan Z, Donnelly D, LaMotte R. Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons. Journal Of Neurophysiology 2006, 95: 1115-1123. PMID: 16424456, DOI: 10.1152/jn.00830.2005.Peer-Reviewed Original ResearchConceptsDorsal root gangliaCCD neuronsRoot gangliaChronic compressionTTX-sensitiveL5 dorsal root gangliaWhole-cell patch-clamp recordingsCell patch-clamp recordingsCutaneous afferent neuronsEnhanced neuronal excitabilityTTX-resistant currentSteady-state activation curvePatch-clamp recordingsCutaneous hyperalgesiaCutaneous neuronsDRG somataAfferent neuronsControl neuronsControl ratsNeuronal somataNeuronal excitabilityAdult ratsSpontaneous activityIntervertebral foraminaLower rheobase