1997
An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion
Zhang J, Song X, LaMotte R. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain 1997, 72: 51-57. PMID: 9272787, DOI: 10.1016/s0304-3959(97)00013-4.Peer-Reviewed Original ResearchConceptsDorsal root gangliaNerve-injured ratsAdrenergic sensitivitySpontaneous activityUninjured nerveDRG cellsRoot gangliaSciatic nerveL5 dorsal root gangliaIntact dorsal root gangliaSelective alpha2-adrenergic agonistRat dorsal root gangliaAbnormal spontaneous activityInjured DRG neuronsSympathetic nervous systemAlpha2-adrenergic agonistDorsal root fibersIntact blood circulationCutaneous hyperalgesiaSpontaneous painDRG neuronsDorsal rootsSpontaneous dischargeC-fibersPeripheral axons
1995
Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat
Xie Y, Zhang J, Petersen M, LaMotte R. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat. Journal Of Neurophysiology 1995, 73: 1811-1820. PMID: 7623082, DOI: 10.1152/jn.1995.73.5.1811.Peer-Reviewed Original ResearchConceptsDorsal root gangliaChronic nerve constrictionMost C-fibersC-fibersNerve constrictionSpontaneous activityInjury siteDRG somataDorsal rootsDorsal root ganglion cellsNerve-injured ratsIpsilateral sciatic nerveL5 dorsal rootAlpha 2 receptorsEffects of norepinephrineDorsal root fibersThermal stimuliUninjured neuronsUninjured ratsNerve injurySympathetic trunkUninjured nerveSympathetic stimulationCutaneous painExcitatory responses
1992
Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.
Torebjörk H, Lundberg L, LaMotte R. Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans. The Journal Of Physiology 1992, 448: 765-780. PMID: 1593489, PMCID: PMC1176227, DOI: 10.1113/jphysiol.1992.sp019069.Peer-Reviewed Original ResearchConceptsMechanical hyperalgesiaCapsaicin injectionIntraneural microstimulationMechanoreceptive inputCapsaicin-induced secondary hyperalgesiaCutaneous innervation territoryArea of hyperalgesiaHealthy human subjectsSecondary hyperalgesiaAlgesic substancesLidocaine anesthesiaInnervation territoryIntense painIntradermal injectionUnmyelinated fibersHyperalgesiaMyelinated fibersC-fibersCentral changesPainAfferent signalsImpulse conductionSuprathreshold stimulationSkin areasTactile sensation
1984
Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human
LaMotte R, Torebjörk H, Robinson C, Thalhammer J. Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human. Journal Of Neurophysiology 1984, 51: 1434-1450. PMID: 6737035, DOI: 10.1152/jn.1984.51.6.1434.Peer-Reviewed Original ResearchConceptsNociceptive afferent fibersDevelopment of hyperalgesiaConditioning stimulusPain ratingsHeat stimulationAfferent fibersHairy skinHeat-evoked dischargesCervical spinal cordMagnitude of painMild heat injurySimilar response magnitudesMean frequencyPoststimulus time histogramsNociceptor activityCutaneous painResponse latencyHyperalgesic skinSpinal cordAwake humansC-fibersAnesthetized monkeysConduction velocityPainHeat stimuliPeripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers
Torebjörk H, LaMotte R, Robinson C. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers. Journal Of Neurophysiology 1984, 51: 325-339. PMID: 6707724, DOI: 10.1152/jn.1984.51.2.325.Peer-Reviewed Original ResearchConceptsConditioning stimulusIntensity-response functionsNormal skinMost subjectsC-mechanoheat nociceptorsPeripheral neural correlateHeat pain sensationMild heat injuryMagnitude ratingsReceptive fieldsHeat injurySupra-threshold stimuliShort-duration stimuliPain thresholdCutaneous painHeat painPain sensationC-fibersPainNociceptorsHairy skinUninjured skinHeat stimulationMagnitude of responseNeuronal correlates
1982
Response properties of high-threshold cutaneous cold receptors in the primate
LaMotte R, Thalhammer J. Response properties of high-threshold cutaneous cold receptors in the primate. Brain Research 1982, 244: 279-287. PMID: 7116176, DOI: 10.1016/0006-8993(82)90086-5.Peer-Reviewed Original ResearchPeripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat
LaMotte R, Thalhammer J, Torebjörk H, Robinson C. Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. Journal Of Neuroscience 1982, 2: 765-781. PMID: 7086482, PMCID: PMC6564351, DOI: 10.1523/jneurosci.02-06-00765.1982.Peer-Reviewed Original ResearchConceptsConditioning stimulusCutaneous hyperalgesiaMild injuryDevelopment of hyperalgesiaHeat injuryMagnitude of hyperalgesiaMild heat injurySingle conditioning stimulusMagnitude of sensitizationPeripheral neural mechanismsReceptive fieldsPeroneal nervePeripheral determinantsCutaneous receptorsC-fibersAwake humansConduction blockAnesthetized monkeysHyperalgesiaNociceptorsPainGlabrous skinNormal skinInjuryHeat stimulation