2017
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family
Sun N, Nasello C, Deng L, Wang N, Zhang Y, Xu Z, Song Z, Kwan K, King R, Pang Z, Xing J, Heiman G, Tischfield J. The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Molecular Psychiatry 2017, 23: 1487-1495. PMID: 28894297, PMCID: PMC5847395, DOI: 10.1038/mp.2017.179.Peer-Reviewed Original ResearchConceptsNonsense-mediated mRNA decayNonsense mutationMultiplex familiesPluripotent stem cellsTD phenotypeDeleterious sequence variantsGenetic architectureMRNA decayHouse bioinformatics pipelineDNA sequencesBioinformatics pipelineTD familyWhole-exome sequencingSequence variantsBiochemical assaysMolecular differencesWhole exomeIsoform levelsStem cellsProtein levelsTD etiologyExome sequencingPNKDHeterozygous nonsense mutationGenes
2006
PANDAS: to treat or not to treat?
King RA. PANDAS: to treat or not to treat? Advances In Neurology 2006, 99: 179-83. PMID: 16536364.Peer-Reviewed Original Research
2000
Pharmacologic Treatment of Tic Disorders
Scahill L, Chappell P, King R, Leckman J. Pharmacologic Treatment of Tic Disorders. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 99-117. PMID: 10674192, DOI: 10.1016/s1056-4993(18)30137-8.Peer-Reviewed Original ResearchConceptsTic disordersTreatment of ADHDAtypical neurolepticsLong-term side effectsNewer atypical neurolepticsFirst-line treatmentTreatment of ticsBotulinum toxin injectionMore studiesUse of stimulantsNonstimulant medicationsToxin injectionPharmacologic treatmentPsychiatric comorbidityStandard treatmentTraditional neurolepticsTarget symptomsSide effectsStimulant medicationMedicationsNeurolepticsAdverse effectsComorbid ADHDDisordersTreatment planning
1996
A Putative Poststreptococcal Case of OCD with Chronic Tic Disorder, Not Otherwise Specified
TUCKER D, LECKMAN J, SCAHILL L, WILF G, LaCAMERA R, CARDONA L, COHEN P, HEIDMANN S, GOLDSTEIN J, JUDGE J, SNYDER E, BULT A, PETERSON B, KING R, LOMBROSO P. A Putative Poststreptococcal Case of OCD with Chronic Tic Disorder, Not Otherwise Specified. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 1684-1691. PMID: 8973076, DOI: 10.1097/00004583-199612000-00022.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersSelective serotonin reuptake inhibitorsSessions of plasmapheresisSerotonin reuptake inhibitorsUpper respiratory symptomsTreatment-resistant casesClinical laboratory dataCognitive behavioral therapyNeuroimmunological perspectiveProphylactic penicillinRespiratory symptomsReuptake inhibitorsObsessive-compulsive disorderConventional pharmacotherapyTreatment optionsSupportive psychotherapyFamily interventionsSeparation anxietyLaboratory dataSubsequent treatmentDisordersPsychotherapyMultiple perspectivesPharmacotherapy
1995
Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics
KING R, SCAHILL L, VITULANO L, SCHWAB-STONE M, TERCYAK K, RIDDLE M. Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1451-1459. PMID: 8543512, DOI: 10.1097/00004583-199511000-00011.Peer-Reviewed Original ResearchRisperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report
LOMBROSO P, SCAHILL L, KING R, LYNCH K, CHAPPELL P, PETERSON B, McDOUGLE C, LECKMAN J. Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1147-1152. PMID: 7559308, DOI: 10.1097/00004583-199509000-00011.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersObsessive-compulsive disorderChronic motor tic disorderYale Global Tic Severity ScaleDopamine-blocking propertiesOpen-label trialFrequent side effectsEfficacy of risperidoneMotor tic disorderShort-term safetyTic Severity ScaleComorbid obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleClinical responseRisperidone treatmentMean ageTic scoreSeverity ScaleSide effectsTourette syndromeComorbid diagnosesTic frequencyWeight gain