2017
Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome
Hirschtritt M, Darrow S, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King R, Pauls D, Budman C, Cath D, Greenberg E, Lyon G, Yu D, McGrath L, McMahon W, Lee P, Delucchi K, Scharf J, Mathews C. Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome. Psychological Medicine 2017, 48: 279-293. PMID: 28651666, PMCID: PMC7909616, DOI: 10.1017/s0033291717001672.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderSymmetry/exactnessTourette syndromeLatent class analysisSymptom patternsADHD symptomsHigher psychiatric comorbidity ratesPsychiatric comorbidity ratesExploratory factor analysisHyperactive subtypeComorbidity ratesTS patientsClinical relevanceSpecific subtypesSum scoreUnique phenotypicHyperactivity disorderSymptomsPhenotypic overlapThree-class solutionTraditional diagnostic boundariesAggressive urgesSyndromeSubtypesDiagnostic boundaries
1995
An Epidemiological Study of Trichotillomania in Israeli Adolescents
KING R, ZOHAR A, RATZONI G, BINDER M, KRON S, DYCIAN A, COHEN D, PAULS D, APTER A. An Epidemiological Study of Trichotillomania in Israeli Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1212-1215. PMID: 7559316, DOI: 10.1097/00004583-199509000-00019.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsComorbid psychopathologyPrevalence of trichotillomaniaSignificant obsessive-compulsive symptomsObsessive-compulsive disorderLifetime prevalenceVocal ticsComorbid disordersEpidemiological studiesPrevalenceAnxiety disordersPhysical fitnessSubsequent reliefTrichotillomaniaCommunity adolescent sampleDisordersSymptomsElevated ratesOverall competencySubjectsAdolescentsReliefPsychopathologyBald spotsIsraeli adolescents
1994
Steroid Hormones and Tourette's Syndrome
PETERSON B, LECKMAN J, SCAHILL L, NAFTOLIN F, KEEFE D, CHAREST N, KING R, HARDIN M, COHEN D. Steroid Hormones and Tourette's Syndrome. Journal Of Clinical Psychopharmacology 1994, 14: 131-135. PMID: 8195454, DOI: 10.1097/00004714-199404000-00008.Peer-Reviewed Original Research
1991
Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment
KING R, RIDDLE M, CHAPPELL P, HARDIN M, ANDERSON G, LOMBROSO P, SCAHILL L. Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 179-186. PMID: 2016219, DOI: 10.1097/00004583-199103000-00003.Peer-Reviewed Original ResearchConceptsFluoxetine treatmentObsessive-compulsive disorderUniversity Clinical Research CenterClinical Research CenterMajor risk factorDrug-induced activationPrior suicidal ideationYounger patientsRisk factorsRegulation of aggressionPatientsSuicidal ideationSelf-destructive behaviorFluoxetineAge 10Apparent associationVulnerable individualsDisordersTreatmentIdeationDe novoHospitalizationSymptoms
1990
Obsessive Compulsive Disorder in Children and Adolescents: Phenomenology and Family History
RIDDLE M, SCAHILL L, KING R, HARDIN M, TOWBIN K, ORT S, LECKMAN J, COHEN D. Obsessive Compulsive Disorder in Children and Adolescents: Phenomenology and Family History. Journal Of The American Academy Of Child & Adolescent Psychiatry 1990, 29: 766-772. PMID: 2228931, DOI: 10.1097/00004583-199009000-00015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCompulsive disorderDisorder diagnosisAnxiety disorder diagnosisObsessive-compulsive symptomsClinical psychiatric assessmentMood disorder diagnosisAssociated psychopathologyContamination concernsResearch implicationsAdolescentsPsychiatric assessmentChildrenDisordersFamily membersPsychopathologyPhenomenologyParentsSymptomsImplicationsFindingsFamily historyBehaviorBehavioral Side Effects of Fluoxetine in Children and Adolescents
RIDDLE M, KING R, HARDIN M, SCAHILL L, ORT S, CHAPPELL P, RASMUSSON A, LECKMAN J. Behavioral Side Effects of Fluoxetine in Children and Adolescents. Journal Of Child And Adolescent Psychopharmacology 1990, 1: 193-198. DOI: 10.1089/cap.1990.1.193.Peer-Reviewed Original ResearchBehavioral side effectsSide effectsObsessive-compulsive symptomsExacerbation of symptomsCompulsive symptomsCommon psychopathological symptomsNeurological statusDosage reductionComplete resolutionSleep disturbancesMotor restlessnessLow dosesUnwanted symptomsFluoxetineSymptomsSubjective sensationPsychopathological symptomsLow dosageAge 8ChildrenDosesRestlessnessFluoxetine Treatment of Children and Adolescents with Tourette's and Obsessive Compulsive Disorders: Preliminary Clinical Experience
RIDDLE M, HARDIN M, KING R, SCAHILL L, WOOLSTON J. Fluoxetine Treatment of Children and Adolescents with Tourette's and Obsessive Compulsive Disorders: Preliminary Clinical Experience. Journal Of The American Academy Of Child & Adolescent Psychiatry 1990, 29: 45-48. PMID: 2295577, DOI: 10.1097/00004583-199001000-00008.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPreliminary clinical experiencePrimary obsessive-compulsive disorderTourette syndromeClinical experienceSelective serotonin uptake inhibitorMild gastrointestinal symptomsSerotonin uptake inhibitorEfficacy of fluoxetineCompulsive disorderFluoxetine administrationGastrointestinal symptomsFluoxetine treatmentResponder rateUptake inhibitorFluoxetineObsessive-compulsive symptomsPatientsAdverse effectsFluoxetine hydrochlorideSyndromeChildrenSymptomsOCD groupAdolescents