1992
RNA-directed actions of 5-fluorouridine in hemin stimulated K-562 erythroleukemia cells.
Heimer R, Sartorelli A. RNA-directed actions of 5-fluorouridine in hemin stimulated K-562 erythroleukemia cells. Cancer Biochemistry Biophysics 1992, 12: 221-39. PMID: 1423209.Peer-Reviewed Original Research
1981
The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Cadman E, Heimer R, Benz C. The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells. Journal Of Biological Chemistry 1981, 256: 1695-1704. PMID: 6161926, DOI: 10.1016/s0021-9258(19)69863-7.Peer-Reviewed Original ResearchConceptsMethotrexate pretreatmentConversion of FUraAddition of leucovorinSynergistic antitumor activityAbility of methotrexateTimes control valuesL1210 cellsEnhancement of intracellularSynergistic cell killingSoft agar cloningMethotrexate treatmentAntipurine effectMethotrexateConcentrations of methotrexateMaximal inhibitionControl valuesIntracellular methotrexateFUraInhibitory effectAntitumor activityExact mechanismIntracellular accumulationAgar cloningSimilar elevationsMicroM methotrexate
1979
Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism
Cadman E, Heimer R, Davis L. Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism. Science 1979, 205: 1135-1137. PMID: 472732, DOI: 10.1126/science.472732.Peer-Reviewed Original Research