2023
METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells
Xiao Z, Wang S, Tian Y, Lv W, Sheng H, Zhan M, Huang Q, Zhang Z, Zhu L, Zhu C, Zhong H, Wen Q, Liu Z, Tan J, Xu Y, Yang M, Liu Y, Flavell R, Yang Q, Cao G, Yin Z. METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells. Cell Reports 2023, 42: 112684. PMID: 37355989, DOI: 10.1016/j.celrep.2023.112684.Peer-Reviewed Original ResearchConceptsM6A methylationMRNA stabilityΓδ T17 cellsEndogenous double-stranded RNADouble-stranded RNAActivation of STAT1MRNA metabolismMRNA turnoverGene expressionKey enzymeDsRNA contentT17 cellsMethylationFunctional specializationRNA contentΓδ TCritical roleMETTL3Numerous aspectsCellsT17Distinct subsetsM6ATranscriptsRNA
2019
To Code or Not to Code: What Is the Linc?
Flavell R. To Code or Not to Code: What Is the Linc? The FASEB Journal 2019, 33: 218.1-218.1. DOI: 10.1096/fasebj.2019.33.1_supplement.218.1.Peer-Reviewed Original ResearchNon-canonical proteinsNon-protein codingNon-coding RNAsUnbiased transcriptomics approachMammalian proteinsNovel ORFsRibosome associationUndiscovered proteinsTranscriptomic approachMethionine codonDistinct proteinsFunctional proteinsImportant transcriptsORFProteinEssential roleGenomeAbsolute requirementFASEB JournalGenesRNABacterial infectionsProteinaceous productsMisannotationsCodon