2014
Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation
Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation. Journal Of Nuclear Medicine 2014, 55: 1445-1451. PMID: 24994931, DOI: 10.2967/jnumed.114.140137.Peer-Reviewed Original ResearchConceptsAdministered activityBlood-pool standardized uptake valuesPhase 1 clinical trialCardiac nerve terminalsCardiac imagingMSv/MBqMean effective doseStandardized uptake valueRadiation doseOLINDA/EXMPatient radiation doseRadiation dose estimatesAdverse eventsBlood pressureWhole-body imagesClinical trialsBlood radioactivityMyocardial innervationNerve terminalsUrinary bladderHealthy subjectsLiver ratioHeart rateLung activityMyocardial uptake
2001
Device‐dependent activity estimation and decay correction of radionuclide mixtures with application to Tc‐94m PET studies
Smith M, Daube‐Witherspoon M, Plascjak P, Szajek L, Carson R, Everett J, Green S, Territo P, Balaban R, Bacharach S, Eckelman W. Device‐dependent activity estimation and decay correction of radionuclide mixtures with application to Tc‐94m PET studies. Medical Physics 2001, 28: 36-45. PMID: 11213920, DOI: 10.1118/1.1333411.Peer-Reviewed Original ResearchConceptsMo targetDecay studiesGamma-ray emissionRadionuclide mixturesHigh-purity germanium detectorTheoretical sensitivity modelPurity germanium detectorDecay correctionDose calibratorExperimental decay curvesRay emissionGermanium detectorTc isotopesMo-94Proton irradiationDecay curvesDecay-corrected activityPET scannerDecay rateBombardmentAnalytic formulaTcPositronsQuantitative PETSensitivity factors
1985
Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems.
Huang SC, Schwaiger M, Carson RE, Carson J, Hansen H, Selin C, Hoffman EJ, MacDonald N, Schelbert HR, Phelps ME. Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems. Journal Of Nuclear Medicine 1985, 26: 616-25. PMID: 3873525.Peer-Reviewed Original Research