2019
Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET
Lu Y, Gallezot JD, Naganawa M, Ren S, Fontaine K, Wu J, Onofrey JA, Toyonaga T, Boutagy N, Mulnix T, Panin VY, Casey ME, Carson RE, Liu C. Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET. Physics In Medicine And Biology 2019, 64: 065002. PMID: 30695768, DOI: 10.1088/1361-6560/ab02c2.Peer-Reviewed Original Research
2015
Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action
Nicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A, Mathy FX, Mercier J, Stockis A, Carson RE, Klitgaard H. Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action. Epilepsia 2015, 57: 201-209. PMID: 26663401, DOI: 10.1111/epi.13267.Peer-Reviewed Original ResearchConceptsFaster onsetAcute seizuresHigh-affinity synaptic vesicle protein 2A ligandNonhuman primate PET studyAudiogenic seizure miceRapid brain entryOnset of actionSingle oral dosingHigh brain permeabilityBlood-brain barrier permeability (BBBP) valuesPrimate PET studyAudiogenic miceBrain entryCaco-2 cellsSeizure micePreclinical evidenceAntiepileptic drugsSusceptible miceBrain levelsBrain penetrationPreclinical dataBrain kineticsOral dosingSingle dosingClinical studies
2001
Device‐dependent activity estimation and decay correction of radionuclide mixtures with application to Tc‐94m PET studies
Smith M, Daube‐Witherspoon M, Plascjak P, Szajek L, Carson R, Everett J, Green S, Territo P, Balaban R, Bacharach S, Eckelman W. Device‐dependent activity estimation and decay correction of radionuclide mixtures with application to Tc‐94m PET studies. Medical Physics 2001, 28: 36-45. PMID: 11213920, DOI: 10.1118/1.1333411.Peer-Reviewed Original ResearchConceptsMo targetDecay studiesGamma-ray emissionRadionuclide mixturesHigh-purity germanium detectorTheoretical sensitivity modelPurity germanium detectorDecay correctionDose calibratorExperimental decay curvesRay emissionGermanium detectorTc isotopesMo-94Proton irradiationDecay curvesDecay-corrected activityPET scannerDecay rateBombardmentAnalytic formulaTcPositronsQuantitative PETSensitivity factors
1985
Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems.
Huang SC, Schwaiger M, Carson RE, Carson J, Hansen H, Selin C, Hoffman EJ, MacDonald N, Schelbert HR, Phelps ME. Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems. Journal Of Nuclear Medicine 1985, 26: 616-25. PMID: 3873525.Peer-Reviewed Original Research