2020
Data-Driven Motion Detection and Event-by-Event Correction for Brain PET: Comparison with Vicra
Lu Y, Naganawa M, Toyonaga T, Gallezot JD, Fontaine K, Ren S, Revilla EM, Mulnix T, Carson RE. Data-Driven Motion Detection and Event-by-Event Correction for Brain PET: Comparison with Vicra. Journal Of Nuclear Medicine 2020, 61: 1397-1403. PMID: 32005770, PMCID: PMC7456171, DOI: 10.2967/jnumed.119.235515.Peer-Reviewed Original ResearchConceptsData-driven algorithmMotion correction methodMotion tracking informationHead motionCentroid of distributionMotion-compensated reconstructionLarge head motionsMotion correction frameworkUser-defined thresholdPET raw dataDynamic datasetsTracking informationImage registrationMotion detectionRaw dataSuch time pointsImage qualityBetter performanceMotion correctionAlgorithmLine of responseCorrection frameworkBrain PET studiesCentral coordinatesTracer kinetic modeling
2017
Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements
Kelada OJ, Rockwell S, Zheng MQ, Huang Y, Liu Y, Booth CJ, Decker RH, Oelfke U, Carson RE, Carlson DJ. Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements. Molecular Imaging And Biology 2017, 19: 893-902. PMID: 28409339, PMCID: PMC5640490, DOI: 10.1007/s11307-017-1083-9.Peer-Reviewed Original ResearchConceptsPositron emission tomographyTumor hypoxic fractionHypoxic fractionEmission tomographyLung cancer radiotherapy patientsPO2 measurementsAbsolute tumor volumeC miceDirect pO2 measurementsBlood ratioClinical impactTumor volumeHypoxia quantificationSubcutaneous tumorsPurposeThe purposeTracer kinetic modelingRadiotherapy patientsPET imagingPatientsPO2 valuesScansPatlak modelTomographyTwo-compartmentTBR