2018
Superior Pituitary Border Analysis in Immunotherapy-Induced Hypophysitis
Pucar D, Boustani AM, Bronen RA, Saperstein L. Superior Pituitary Border Analysis in Immunotherapy-Induced Hypophysitis. Clinical Nuclear Medicine 2018, 43: 284-286. PMID: 29401149, DOI: 10.1097/rlu.0000000000001981.Peer-Reviewed Educational MaterialsConceptsSinus diseasePituitary swellingSevere headacheVisual disturbancesLaboratory findingsMetastatic melanomaPituitary abnormalitiesRetrospective analysisContrast CTNoncontrast CTPituitary hormonesHypophysitisHeadacheDiseaseDiagnosisCTLow levelsNivolumabHypermetabolismImmunotherapyPETMelanomaAbnormalitiesFindingsHormone
2017
Long-term outcomes of tissue-based ACTH-antibody assay-guided transsphenoidal resection of pituitary adenomas in Cushing disease.
Erfe JM, Perry A, McClaskey J, Inzucchi SE, James WS, Eid T, Bronen RA, Mahajan A, Huttner A, Santos F, Spencer D. Long-term outcomes of tissue-based ACTH-antibody assay-guided transsphenoidal resection of pituitary adenomas in Cushing disease. Journal Of Neurosurgery 2017, 129: 629-641. PMID: 29027854, DOI: 10.3171/2017.3.jns162245.Peer-Reviewed Original ResearchConceptsTranssphenoidal resectionMRI studiesCushing's diseaseCortisol levelsLong-term corticosteroid therapyUrinary free cortisol levelsLong-term disease remissionLong-term patient outcomesResults Fourteen patientsLong-term outcomesPostoperative MRI studiesSurgical tumor samplesFree cortisol levelsPreoperative MRI studiesPrecise tumor localizationACTH antibodiesPituitary microCorticosteroid therapyStudy patientsDisease remissionFourteen patientsRemission rateRetrospective reviewTreatment failureCure rate
2014
Brainstem melanomas presenting as a cavernous malformation
Lu AY, Patel AR, Kuzmik GA, Atsina K, Bronen RA, Jabbour PM, Hasan DM, Vortmeyer AO, Welch BG, Bulsara KR. Brainstem melanomas presenting as a cavernous malformation. Neurochirurgie 2014, 60: 184-187. PMID: 24856047, DOI: 10.1016/j.neuchi.2014.02.005.Peer-Reviewed Case Reports and Technical NotesConceptsCavernous malformationsClinical courseWhole-brain radiation therapyAcute pontine hemorrhageRight dorsal midbrainWhole brain radiationAggressive clinical courseRepeat hemorrhageMelanoma presentingSurgical resectionBrainstem hemorrhagePontine hemorrhagePoor prognosisTreatment modalitiesHemorrhagic lesionsRadiation therapyDorsal midbrainStereotactic radiosurgeryMelanoma lesionsLesionsHemorrhageMelanomaMalformationsResectionBrainstem
2004
Long-term outcome after epilepsy surgery for focal cortical dysplasia.
Cohen-Gadol AA, Ozduman K, Bronen RA, Kim JH, Spencer DD. Long-term outcome after epilepsy surgery for focal cortical dysplasia. Journal Of Neurosurgery 2004, 101: 55-65. PMID: 15255252, DOI: 10.3171/jns.2004.101.1.0055.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasiaImproved seizure outcomeLong-term outcomesCortical dysplasiaClear marginsEpileptogenic zoneSeizure outcomeMean ageMean durationRisk factorsCortical developmentIntracranial monitoringObvious risk factorsRare disabling seizuresTransient sensorimotor deficitsMultiple subpial transectionsSubgroup of patientsExtent of resectionVisual field defectsInclusion of patientsNormal functional anatomyReports of outcomesMagnetic resonance imagingFunctional MR imagingPartial lesionectomy
2003
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesBasal gangliaCaudate nucleus volumeTourette syndromeGanglia volumesObsessive-compulsive disorderLenticular nucleus volumesTic symptomsNucleus volumeGilles dePathophysiology of TSPrior neuroleptic exposureHealthy control subjectsSeverity of ticsComorbid obsessive-compulsive disorderGreat clinical relevanceAttention-deficit/hyperactivity disorder (ADHD) symptomsHyperactivity disorder symptomsRepeated-measures analysisNeuroleptic exposureControl subjectsFunctional disturbancesTrait abnormalityClinical relevanceGanglia
2000
Choroid plexus changes after temporal lobectomy.
Saluja S, Sato N, Kawamura Y, Coughlin W, Putman C, Spencer D, Sze G, Bronen R. Choroid plexus changes after temporal lobectomy. American Journal Of Neuroradiology 2000, 21: 1650-3. PMID: 11039344, PMCID: PMC8174865.Peer-Reviewed Original ResearchConceptsTemporal lobectomyChoroid plexusPostoperative changesResection siteNormal postoperative changesRecurrent brain tumorsContrast-enhanced T1-weighted imagesPresence of infectionContrast-enhanced MR imagingDegree of enhancementT1-weighted imagesChoroid plexus changesHippocampal sclerosisRecurrent tumorsIntractable epilepsyNodular patternPathologic changesPostoperative siteLobectomyBrain tumorsEnhancement patternSurgical manipulationPlexusMorphologic changesMR imagingMR Imaging and Histologic Features of Subinsular Bright Spots on T2-weighted MR Images: Virchow-Robin Spaces of the Extreme Capsule and Insular Cortex
Song C, Kim J, Kier E, Bronen R. MR Imaging and Histologic Features of Subinsular Bright Spots on T2-weighted MR Images: Virchow-Robin Spaces of the Extreme Capsule and Insular Cortex. Radiology 2000, 214: 671-677. PMID: 10715028, DOI: 10.1148/radiology.214.3.r00mr17671.Peer-Reviewed Original ResearchConceptsInsular cortexExtreme capsuleMR imagingControl subjectsBrain specimensPerivascular spacesFormalin-fixed brain specimensFluid-attenuated inversion recovery sequencesVirchow-Robin spacesT2-weighted magnetic resonance imagesCoronal T2-weighted imagesT2-weighted imagesCoronal MR imagesHigh signal intensityT2-weighted MR imagesInversion recovery sequenceHistologic featuresHistologic findingsCerebrospinal fluidMR imagesPatientsWhite matterPathologic conditionsGross anatomic inspectionMagnetic resonance images
1998
Surgical outcome in occipital lobe epilepsy: Implications for pathophysiology
Aykut‐Bingol C, Bronen R, Kim J, Spencer D, Spencer S. Surgical outcome in occipital lobe epilepsy: Implications for pathophysiology. Annals Of Neurology 1998, 44: 60-69. PMID: 9667593, DOI: 10.1002/ana.410440112.Peer-Reviewed Original ResearchConceptsOccipital lobe epilepsyClinical seizure characteristicsFocal cortical dysplasiaLobe epilepsyLobe locationPathological substrateSeizure characteristicsSurgical outcomesCortical dysplasiaSurgical approachSurgical proceduresRefractory occipital lobe epilepsyDevelopmental abnormalitiesOccipital lobe seizuresChronic inflammatory changesSturge-Weber syndromeMain pathological substrateOccipital lobe tumorElectroclinical variablesElectroclinical featuresMost patientsSeizure controlChronic epilepsyInflammatory changesLobe tumors
1997
Postoperative changes in the brain: MR imaging findings in patients without neoplasms.
Sato N, Bronen R, Sze G, Kawamura Y, Coughlin W, Putman C, Spencer D. Postoperative changes in the brain: MR imaging findings in patients without neoplasms. Radiology 1997, 204: 839-46. PMID: 9280269, DOI: 10.1148/radiology.204.3.9280269.Peer-Reviewed Original ResearchConceptsPostoperative MR imagesPostoperative changesDural enhancementEnhancement patternThin linear enhancementContrast enhancement patternMagnetic resonance imagingMR imagesSurgical marginsTemporal lobectomyNeoplastic changesExtraaxial fluidIntracranial airContrast material-enhanced MR imagesDay 5Day 51Day 30Resonance imagingSurgeryBrainPatientsTime courseContrast enhancementLinear enhancementDaysQualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery.
Bronen RA, Fulbright RK, King D, Kim JH, Spencer SS, Spencer DD, Lange RC. Qualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery. American Journal Of Roentgenology 1997, 169: 875-82. PMID: 9275915, DOI: 10.2214/ajr.169.3.9275915.Peer-Reviewed Original ResearchConceptsFebrile seizure historyTemporal lobe epilepsyRefractory temporal lobe epilepsyHippocampal sclerosisSeizure historySeizure outcomeLobe epilepsyHistologic findingsNonspecific gliosisHippocampal atrophyIntractable temporal lobe epilepsyMild hippocampal atrophySimilar clinical conditionsMR imaging diagnosisPositive predictive valueMR imagesSignal intensity changesSegmental findingsNormal findingsClinical parametersNeuronal densityRetrospective studyClinical conditionsSclerosisSurgeryPositron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder
Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 246-254. PMID: 9075465, DOI: 10.1001/archpsyc.1997.01830150070011.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdministration of yohimbineNorepinephrine releaseHealthy subjectsHealthy age-matched control subjectsAge-matched control subjectsStress disorderDouble-blind fashionPositron emission tomography (PET) measurementsBrain metabolic responsesCerebral metabolic correlatesBrain norepinephrine releaseSymptoms of anxietyPositron emission tomographyBrain metabolismControl subjectsYohimbine administrationPreclinical studiesMetabolic correlatesCaudate nucleusPatientsYohimbineVietnam combat veteransEmission tomographyOrbitofrontal cortexMagnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison regionEconomic impact of replacing CT with MR imaging for refractory epilepsy
Bronen R, Fulbright R, Spencer S, Spencer D, Kim J, Lange R. Economic impact of replacing CT with MR imaging for refractory epilepsy. Magnetic Resonance Imaging 1997, 15: 857-862. PMID: 9309616, DOI: 10.1016/s0730-725x(97)00047-7.Peer-Reviewed Original ResearchConceptsPreoperative evaluationRefractory epilepsyPositive imaging findingsRefractory epilepsy patientsPositive magnetic resonanceMagnetic resonanceIntracranial electroencephalogram monitoringSurgical ameliorationNormal CTImaging findingsPreoperative localizationIntractable epilepsyVascular lesionsEpileptogenic zoneElectroencephalogram monitoringPreoperative CTEpilepsy patientsPatientsMR imagingEpilepsyCTVascular substratesHealth costsLesionsSurgery
1996
Comparison of technetium-99m-HMPAO and technetium-99m-ECD cerebral SPECT images in Alzheimer's disease.
van Dyck CH, Lin CH, Smith EO, Wisniewski G, Cellar J, Robinson R, Narayan M, Bennett A, Delaney RC, Bronen RA, Hoffer PB. Comparison of technetium-99m-HMPAO and technetium-99m-ECD cerebral SPECT images in Alzheimer's disease. Journal Of Nuclear Medicine 1996, 37: 1749-55. PMID: 8917168.Peer-Reviewed Original ResearchConceptsControl subjectsAD patientsAlzheimer's diseaseAge-matched control subjectsBrain structuresBrain perfusion agentHigh diagnostic accuracyTechnetium-99mCysteinate dimerHealthy subjectsPatientsDiagnostic groupsPerfusion agentDiagnostic accuracyDiseaseSignificant differencesDiagnostic toolSPECT imagesSubjectsPurported advantagesCharacteristic analysisSignificant interactionCerebral imagesAnalysis of varianceCount densityRefractory epilepsy: comparison of MR imaging, CT, and histopathologic findings in 117 patients.
Bronen RA, Fulbright RK, Spencer DD, Spencer SS, Kim JH, Lange RC, Sutilla C. Refractory epilepsy: comparison of MR imaging, CT, and histopathologic findings in 117 patients. Radiology 1996, 201: 97-105. PMID: 8816528, DOI: 10.1148/radiology.201.1.8816528.Peer-Reviewed Original Research
1995
MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder
Bremner J, Randall P, Scott T, Bronen R, Seibyl J, Southwick S, Delaney R, McCarthy G, Charney D, Innis R. MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder. American Journal Of Psychiatry 1995, 152: 973-981. PMID: 7793467, PMCID: PMC3233767, DOI: 10.1176/ajp.152.7.973.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCombat-related posttraumatic stress disorderSmaller right hippocampal volumeRight hippocampal volumeVerbal memoryHippocampal volumeStress disorderPTSD patientsShort-term verbal memoryShort-term memoryWechsler Memory ScaleComparison subjectsVietnam combat veteransMemory ScaleCombat veteransYears of educationMagnetic resonance imagingBrain regionsMemoryBrain structuresFunctional deficitsNeurotoxic effectsPsychiatric disordersAlcohol abusePatients
1994
CT-Guided Percutaneous Insertion of Interstitial Radiotherapy Catheters in Head and Neck Tumors
Bronen R, Lee G, Son Y, Healy G, Meli J, Sasaki C. CT-Guided Percutaneous Insertion of Interstitial Radiotherapy Catheters in Head and Neck Tumors. Journal Of Computer Assisted Tomography 1994, 18: 163. PMID: 8282876, DOI: 10.1097/00004728-199401000-00039.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrachytherapyCatheterizationHead and Neck NeoplasmsHumansMaleMiddle AgedTomography, X-Ray ComputedConceptsNeck tumorsPercutaneous insertionRadiation therapyDetailed anatomical localizationPalliative radiation therapyTherapy catheterInterstitial radiation therapyPrecise percutaneous placementInoperable headTumor sizePercutaneous placementCT guidanceSurgical placementAnatomical localizationCatheterTumorsPatientsVascular structuresTherapyCTHeadPainPlacement
1993
MR findings after depth electrode implantation for medically refractory epilepsy.
Merriam M, Bronen R, Spencer D, McCarthy G. MR findings after depth electrode implantation for medically refractory epilepsy. American Journal Of Neuroradiology 1993, 14: 1343-6. PMID: 8279329, PMCID: PMC8367502.Peer-Reviewed Original ResearchConceptsDepth electrode implantationProbe tractRefractory epilepsyChronic changesElectrode implantationEvidence of gliosisElectrode placementProbe placementRare complicationDepth electrode placementRetrospective reviewIntraparenchymal hemorrhageSignificant hemorrhageSeizure focusBrain parenchymaSignal abnormalitiesStereotactic placementLower incidenceMR findingsAngiographic dataHemorrhagePatientsDepth electrodesSpin-echo imagesMR scans
1992
Efficacy of Gadoteridol for Magnetic Resonance Imaging of the Brain and Spine
RUNGE V, BRONEN R, DAVIS K. Efficacy of Gadoteridol for Magnetic Resonance Imaging of the Brain and Spine. Investigative Radiology 1992, 27: s33. PMID: 1506150, DOI: 10.1097/00004424-199208001-00006.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingEfficacy of gadoteridolResonance imagingCentral nervous system pathologyMulticenter clinical trialNervous system pathologyIntravenous contrast agentsMagnetic resonance scansVisualization of pathologyRadiologic evidencePostcontrast scansSpinal lesionsClinical trialsIntravenous administrationPathologic lesionsSpinal pathologySystem pathologyResonance scansPrecontrast imagesSpinal casesIntracranial casesPathologyGadoteridolLesion bordersPatientsQuantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function
Lencz T, McCarthy G, Bronen R, Scott T, Inserni J, Sass K, Novelly R, Kim J, Spencer D. Quantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function. Annals Of Neurology 1992, 31: 629-637. PMID: 1514774, DOI: 10.1002/ana.410310610.Peer-Reviewed Original ResearchConceptsControl subjectsLeft temporal lobeTemporal lobeSeizure focusNeuronal densityHippocampal measurementsRight-handed control subjectsMagnetic resonance imagesHippocampal neuronal densityTemporal lobe originEpileptic temporal lobeTemporal lobe epilepsySignificant correlationQuantitative magnetic resonanceRefractory epilepsyLobe epilepsyPatient groupSelective Reminding TestHippocampal ratioLeft hippocampusHippocampal subfieldsPatientsWechsler Memory ScaleNeuropsychological functionHippocampus