2006
Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease
Basso M, Yang J, Warren L, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Research 2006, 146: 251-261. PMID: 16524704, DOI: 10.1016/j.pscychresns.2006.01.007.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingAD patientsAmygdaloid volumesAlzheimer's diseaseHealthy controlsHippocampal volumeAlzheimer's Disease Assessment Scale-CognitionMedial temporal lobe atrophyTemporal lobe atrophyOlder healthy subjectsADAS-Cog subscaleHealthy control samplesLobe atrophyAD groupHealthy subjectsAnalysis of covarianceMRI studiesProdromal stagePatientsResonance imagingMildest symptomsNeuropsychological assessmentNeuropsychological performanceHippocampusDisease
2002
Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression
Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD. Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression. American Journal Of Psychiatry 2002, 159: 2072-2080. PMID: 12450959, PMCID: PMC3230324, DOI: 10.1176/appi.ajp.159.12.2072.Peer-Reviewed Original ResearchConceptsSmaller hippocampal volumesMajor depressive disorderHippocampal volumeDepressive disorderDepressed subjectsDepressed womenHealthy subjectsChildhood abuseUnipolar major depressive disorderRight hippocampal volumeCoronal MRI scansAdrenal axisDepressed patientsMajor depressionControl brain regionsTemporal lobeWhole hippocampusComparison subjectsMRI scansTrauma AssociatedEarly childhood traumaFemale volunteersWhole brainBrain regionsStudy participants
2000
Choroid plexus changes after temporal lobectomy.
Saluja S, Sato N, Kawamura Y, Coughlin W, Putman C, Spencer D, Sze G, Bronen R. Choroid plexus changes after temporal lobectomy. American Journal Of Neuroradiology 2000, 21: 1650-3. PMID: 11039344, PMCID: PMC8174865.Peer-Reviewed Original ResearchConceptsTemporal lobectomyChoroid plexusPostoperative changesResection siteNormal postoperative changesRecurrent brain tumorsContrast-enhanced T1-weighted imagesPresence of infectionContrast-enhanced MR imagingDegree of enhancementT1-weighted imagesChoroid plexus changesHippocampal sclerosisRecurrent tumorsIntractable epilepsyNodular patternPathologic changesPostoperative siteLobectomyBrain tumorsEnhancement patternSurgical manipulationPlexusMorphologic changesMR imaging
1998
MR of mesial temporal sclerosis: how much is enough?
Bronen R. MR of mesial temporal sclerosis: how much is enough? American Journal Of Neuroradiology 1998, 19: 15-8. PMID: 9432152, PMCID: PMC8337351.Commentaries, Editorials and Letters
1997
Topographic distribution of seizure onset and hippocampal atrophy: Relationship between MRI and depth EEG
King D, Bronen R, Spencer D, Spencer S. Topographic distribution of seizure onset and hippocampal atrophy: Relationship between MRI and depth EEG. Clinical Neurophysiology 1997, 103: 692-697. PMID: 9546496, DOI: 10.1016/s0013-4694(97)00090-4.Peer-Reviewed Original ResearchConceptsMedial temporal lobe epilepsyMagnetic resonance imagingSegmental atrophyHippocampal atrophyIctal onsetCell lossTopographic distributionDepth EEGHippocampal cell lossAnterior temporal lobectomyTemporal lobe epilepsyHippocampal depth electrodesMedial temporal structuresDistribution of onsetMost patientsTemporal lobectomyFocal onsetLobe epilepsyExcellent outcomesIctal recordingsDentate gyrusHippocampal segmentsSeizure onsetSubdural stripsDepth electrode contactsQualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery.
Bronen RA, Fulbright RK, King D, Kim JH, Spencer SS, Spencer DD, Lange RC. Qualitative MR imaging of refractory temporal lobe epilepsy requiring surgery: correlation with pathology and seizure outcome after surgery. American Journal Of Roentgenology 1997, 169: 875-82. PMID: 9275915, DOI: 10.2214/ajr.169.3.9275915.Peer-Reviewed Original ResearchConceptsFebrile seizure historyTemporal lobe epilepsyRefractory temporal lobe epilepsyHippocampal sclerosisSeizure historySeizure outcomeLobe epilepsyHistologic findingsNonspecific gliosisHippocampal atrophyIntractable temporal lobe epilepsyMild hippocampal atrophySimilar clinical conditionsMR imaging diagnosisPositive predictive valueMR imagesSignal intensity changesSegmental findingsNormal findingsClinical parametersNeuronal densityRetrospective studyClinical conditionsSclerosisSurgeryEmbryology of the human fetal hippocampus: MR imaging, anatomy, and histology.
Kier EL, Kim JH, Fulbright RK, Bronen RA. Embryology of the human fetal hippocampus: MR imaging, anatomy, and histology. American Journal Of Neuroradiology 1997, 18: 525-32. PMID: 9090416, PMCID: PMC8338418.Peer-Reviewed Original ResearchConceptsDentate gyrusCornu ammonisHippocampal sulcusGestational ageMR imagingTemporal lobeCA1-3 fieldsWeeks gestational ageHuman fetal hippocampusHuman fetal specimensWeeks' gestationAdult hippocampusFetal hippocampusCA4 fieldsCA3 fieldParahippocampal gyrusHippocampusHistologic sectionsGyrusAmmonisHippocampal anatomyFetal specimensSimilar ageMedial surfaceSulcusMagnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region
1995
Limbic lobe embryology and anatomy: dissection and MR of the medial surface of the fetal cerebral hemisphere.
Kier EL, Fulbright RK, Bronen RA. Limbic lobe embryology and anatomy: dissection and MR of the medial surface of the fetal cerebral hemisphere. American Journal Of Neuroradiology 1995, 16: 1847-53. PMID: 8693985, PMCID: PMC8338224.Peer-Reviewed Original ResearchConceptsHippocampal formationCorpus callosumCerebral hemispheresFetal specimensHippocampal sulcusFrontal lobeMedial surfaceLarger hippocampal formationsFetal cerebralParaterminal gyrusGestational ageSubcallosal areaParahippocampus gyrusLimbic lobeCingulate gyrusTemporal lobeParahippocampal gyrusComplex anatomyGyrusCallosumMR anatomyAnterior partWeeksSimilar ageSulcusMRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder
Bremner J, Randall P, Scott T, Bronen R, Seibyl J, Southwick S, Delaney R, McCarthy G, Charney D, Innis R. MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder. American Journal Of Psychiatry 1995, 152: 973-981. PMID: 7793467, PMCID: PMC3233767, DOI: 10.1176/ajp.152.7.973.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCombat-related posttraumatic stress disorderSmaller right hippocampal volumeRight hippocampal volumeVerbal memoryHippocampal volumeStress disorderPTSD patientsShort-term verbal memoryShort-term memoryWechsler Memory ScaleComparison subjectsVietnam combat veteransMemory ScaleCombat veteransYears of educationMagnetic resonance imagingBrain regionsMemoryBrain structuresFunctional deficitsNeurotoxic effectsPsychiatric disordersAlcohol abusePatientsIs there any role for gadopentetate dimeglumine administration when searching for mesial temporal sclerosis in patients with seizures?
Bronen R. Is there any role for gadopentetate dimeglumine administration when searching for mesial temporal sclerosis in patients with seizures? American Journal Of Roentgenology 1995, 164: 503. PMID: 7839999, DOI: 10.2214/ajr.164.2.7839999.Commentaries, Editorials and LettersRegional distribution of MR findings in hippocampal sclerosis.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD, al-Rodhan NR. Regional distribution of MR findings in hippocampal sclerosis. American Journal Of Neuroradiology 1995, 16: 1193-200. PMID: 7677010, PMCID: PMC8337833.Peer-Reviewed Original ResearchConceptsHippocampal sclerosisHippocampal bodyHippocampal headMR findingsHippocampal tailMR abnormalitiesLimbic structuresAbnormal MR findingsConsecutive patientsIpsilateral hippocampusMost patientsSignal changesSeizure generatorPathologic analysisHyperintense signalRegional atrophyEntire hippocampusPatientsSclerosisHippocampusAmygdalaAtrophyMR changesMR scansWidespread involvementMR characteristics of neoplasms and vascular malformations associated with epilepsy
Bronen R, Fulbright R, Spencer D, Spencer S, Kim J, Lange R. MR characteristics of neoplasms and vascular malformations associated with epilepsy. Magnetic Resonance Imaging 1995, 13: 1153-1162. PMID: 8750330, DOI: 10.1016/0730-725x(95)02026-p.Peer-Reviewed Original ResearchConceptsVascular malformationsCalvarial remodellingPathologic categoriesAdjacent tissuesTemporal lobe locationTypical imaging featuresMR characteristicsBlinded retrospective analysisMagnetic resonanceRefractory epilepsyPathologic findingsCortical involvementEpileptogenic substratePathologic substrateVascular lesionsImaging featuresCommon siteRetrospective analysisTemporal lobeLobe locationEpilepsyLesionsMalformationsNeoplasmsMR scans
1994
Quantitative MR for epilepsy: a clinical and research tool?
Bronen R, Anderson A, Spencer D. Quantitative MR for epilepsy: a clinical and research tool? American Journal Of Neuroradiology 1994, 15: 1157-60. PMID: 8073987, PMCID: PMC8333470.Commentaries, Editorials and Letters
1992
Epilepsy: the role of MR imaging.
Bronen R. Epilepsy: the role of MR imaging. American Journal Of Roentgenology 1992, 159: 1165-74. PMID: 1442376, DOI: 10.2214/ajr.159.6.1442376.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMR imagingTemporal lobe epilepsyLong TR imagesPositron emission tomographySingle photon emissionEpileptogenic abnormalitiesHippocampal sclerosisPreoperative evaluationSurgical treatmentLobe epilepsyHigh success rateCommon causeUncontrollable seizuresEmission tomographyTechnique of choiceEpilepsyFunctional imagingSuccess ratePatientsSeizuresTR imagesImagingTomographyMRSclerosisQuantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function
Lencz T, McCarthy G, Bronen R, Scott T, Inserni J, Sass K, Novelly R, Kim J, Spencer D. Quantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function. Annals Of Neurology 1992, 31: 629-637. PMID: 1514774, DOI: 10.1002/ana.410310610.Peer-Reviewed Original ResearchConceptsControl subjectsLeft temporal lobeTemporal lobeSeizure focusNeuronal densityHippocampal measurementsRight-handed control subjectsMagnetic resonance imagesHippocampal neuronal densityTemporal lobe originEpileptic temporal lobeTemporal lobe epilepsySignificant correlationQuantitative magnetic resonanceRefractory epilepsyLobe epilepsyPatient groupSelective Reminding TestHippocampal ratioLeft hippocampusHippocampal subfieldsPatientsWechsler Memory ScaleNeuropsychological functionHippocampusHippocampal and limbic terminology.
Bronen R. Hippocampal and limbic terminology. American Journal Of Neuroradiology 1992, 13: 943-5. PMID: 1590195, PMCID: PMC8331700.Peer-Reviewed Original Research
1991
Imaging findings in hippocampal sclerosis: correlation with pathology.
Bronen R, Cheung G, Charles J, Kim J, Spencer D, Spencer S, Sze G, McCarthy G. Imaging findings in hippocampal sclerosis: correlation with pathology. American Journal Of Neuroradiology 1991, 12: 933-40. PMID: 1950925, PMCID: PMC8333515.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyCryptogenic temporal lobe epilepsyHippocampal sclerosisLobe epilepsyHippocampal atrophyNeuronal densityPathologic criteriaQualitative histologic findingsUnilateral hippocampal atrophyNeuronal cell lossImportant therapeutic consequencesPreoperative radiologic imagingAdjacent white matterLong TR scansGranular cell layerTemporal lobectomyPreoperative diagnosisIntractable epilepsyRadiologic imagingHistologic findingsSurgical specimensCornu ammonisTherapeutic consequencesMR findingsTemporal lobeMRI of the temporal lobe: Normal variations, with special reference toward epilepsy
Bronen R, Cheung G. MRI of the temporal lobe: Normal variations, with special reference toward epilepsy. Magnetic Resonance Imaging 1991, 9: 501-507. PMID: 1779721, DOI: 10.1016/0730-725x(91)90036-l.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingTemporal hornTemporal lobeCollateral sulcusCoronal magnetic resonance imagingTemporal horn dilatationMild asymmetryRight temporal lobeTemporal lobe structuresHippocampal sclerosisChoroidal fissureNormal variationMild enlargementFrequent findingHippocampal headNormal volunteersWhite matterAlzheimer's diseaseResonance imagingLobe structuresOccipitotemporal sulcusAdjacent vesselsHead rotationSclerosisSulcusRelationship of hippocampus and amygdala to coronal MRI landmarks
Bronen R, Cheung G. Relationship of hippocampus and amygdala to coronal MRI landmarks. Magnetic Resonance Imaging 1991, 9: 449-457. PMID: 1881265, DOI: 10.1016/0730-725x(91)90434-n.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmygdalaHippocampusHumansLimbic SystemMagnetic Resonance ImagingMiddle Aged