2006
Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease
Basso M, Yang J, Warren L, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Research 2006, 146: 251-261. PMID: 16524704, DOI: 10.1016/j.pscychresns.2006.01.007.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingAD patientsAmygdaloid volumesAlzheimer's diseaseHealthy controlsHippocampal volumeAlzheimer's Disease Assessment Scale-CognitionMedial temporal lobe atrophyTemporal lobe atrophyOlder healthy subjectsADAS-Cog subscaleHealthy control samplesLobe atrophyAD groupHealthy subjectsAnalysis of covarianceMRI studiesProdromal stagePatientsResonance imagingMildest symptomsNeuropsychological assessmentNeuropsychological performanceHippocampusDisease
2002
Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression
Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD. Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression. American Journal Of Psychiatry 2002, 159: 2072-2080. PMID: 12450959, PMCID: PMC3230324, DOI: 10.1176/appi.ajp.159.12.2072.Peer-Reviewed Original ResearchConceptsSmaller hippocampal volumesMajor depressive disorderHippocampal volumeDepressive disorderDepressed subjectsDepressed womenHealthy subjectsChildhood abuseUnipolar major depressive disorderRight hippocampal volumeCoronal MRI scansAdrenal axisDepressed patientsMajor depressionControl brain regionsTemporal lobeWhole hippocampusComparison subjectsMRI scansTrauma AssociatedEarly childhood traumaFemale volunteersWhole brainBrain regionsStudy participants
1997
Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder
Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 246-254. PMID: 9075465, DOI: 10.1001/archpsyc.1997.01830150070011.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdministration of yohimbineNorepinephrine releaseHealthy subjectsHealthy age-matched control subjectsAge-matched control subjectsStress disorderDouble-blind fashionPositron emission tomography (PET) measurementsBrain metabolic responsesCerebral metabolic correlatesBrain norepinephrine releaseSymptoms of anxietyPositron emission tomographyBrain metabolismControl subjectsYohimbine administrationPreclinical studiesMetabolic correlatesCaudate nucleusPatientsYohimbineVietnam combat veteransEmission tomographyOrbitofrontal cortexMagnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region
1996
Comparison of technetium-99m-HMPAO and technetium-99m-ECD cerebral SPECT images in Alzheimer's disease.
van Dyck CH, Lin CH, Smith EO, Wisniewski G, Cellar J, Robinson R, Narayan M, Bennett A, Delaney RC, Bronen RA, Hoffer PB. Comparison of technetium-99m-HMPAO and technetium-99m-ECD cerebral SPECT images in Alzheimer's disease. Journal Of Nuclear Medicine 1996, 37: 1749-55. PMID: 8917168.Peer-Reviewed Original ResearchConceptsControl subjectsAD patientsAlzheimer's diseaseAge-matched control subjectsBrain structuresBrain perfusion agentHigh diagnostic accuracyTechnetium-99mCysteinate dimerHealthy subjectsPatientsDiagnostic groupsPerfusion agentDiagnostic accuracyDiseaseSignificant differencesDiagnostic toolSPECT imagesSubjectsPurported advantagesCharacteristic analysisSignificant interactionCerebral imagesAnalysis of varianceCount density