2002
Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression
Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD. Childhood Trauma Associated With Smaller Hippocampal Volume in Women With Major Depression. American Journal Of Psychiatry 2002, 159: 2072-2080. PMID: 12450959, PMCID: PMC3230324, DOI: 10.1176/appi.ajp.159.12.2072.Peer-Reviewed Original ResearchConceptsSmaller hippocampal volumesMajor depressive disorderHippocampal volumeDepressive disorderDepressed subjectsDepressed womenHealthy subjectsChildhood abuseUnipolar major depressive disorderRight hippocampal volumeCoronal MRI scansAdrenal axisDepressed patientsMajor depressionControl brain regionsTemporal lobeWhole hippocampusComparison subjectsMRI scansTrauma AssociatedEarly childhood traumaFemale volunteersWhole brainBrain regionsStudy participants
1997
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region