2006
Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease
Basso M, Yang J, Warren L, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Research 2006, 146: 251-261. PMID: 16524704, DOI: 10.1016/j.pscychresns.2006.01.007.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingAD patientsAmygdaloid volumesAlzheimer's diseaseHealthy controlsHippocampal volumeAlzheimer's Disease Assessment Scale-CognitionMedial temporal lobe atrophyTemporal lobe atrophyOlder healthy subjectsADAS-Cog subscaleHealthy control samplesLobe atrophyAD groupHealthy subjectsAnalysis of covarianceMRI studiesProdromal stagePatientsResonance imagingMildest symptomsNeuropsychological assessmentNeuropsychological performanceHippocampusDisease
2005
Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease
Basso M, Gelernter J, Yang J, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease. Neurobiology Of Aging 2005, 27: 1416-1424. PMID: 16182410, DOI: 10.1016/j.neurobiolaging.2005.08.002.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD patientsAPOE epsilon4AD groupImportant genetic risk factorApolipoprotein E epsilon4Regional brain atrophyAPOE epsilon4 alleleElderly control subjectsNormal elderly control subjectsGenetic risk factorsAmygdaloid volumesBrain atrophyControl subjectsEpsilon4 carriersRisk factorsEpsilon4 alleleHippocampal volumeEpsilon4 doseAnalysis of covarianceDisease severityPatientsEpsilon4AmygdalaAtrophy