2021
The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration
Rahimi N, Ho R, Chandler K, De La Cena K, Amraei R, Mitchel A, Engblom N, Costello C. The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration. Journal Of Biomedical Science 2021, 28: 61. PMID: 34503512, PMCID: PMC8427838, DOI: 10.1186/s12929-021-00757-z.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsCell MovementMembrane GlycoproteinsMiceMice, KnockoutMicrofilament ProteinsTubulinConceptsMitotic spindle organizationERM familyΑ-tubulinSpindle organizationCell migrationApical localizationN-terminal ERM domainCRISPR/Cas9-mediated knockoutMitotic spindle assemblyCell-cell adhesionCas9-mediated knockoutFilopodia-like protrusionsNovel tumor suppressorComplex functional interplayActin organizationERM domainLysine acetylationTMIGD1Spindle assemblyCarboxyl terminusFunctional interplayMoesinCell cycleTumor suppressorEzrin
2020
Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells
De La Cena K, Ho R, Amraei R, Woolf N, Tashjian J, Zhao Q, Richards S, Walker J, Huang J, Chitalia V, Rahimi N. Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells. American Journal Of Pathology 2020, 191: 157-167. PMID: 33129760, PMCID: PMC7788663, DOI: 10.1016/j.ajpath.2020.09.015.Peer-Reviewed Original ResearchConceptsCell cycleColorectal cancerCell cycle checkpoint arrestCell cycle inhibitor proteinsNovel tumor suppressor geneFull molecular mechanismsPutative tumor suppressorColon cancer cellsTumor suppressor geneG2/M phaseSporadic human colorectal cancerNormal intestinal epithelial cellsEpigenetic mechanismsCheckpoint arrestTMIGD1Inhibitor proteinNovel potential therapeutic targetIntestinal epithelial cellsMolecular mechanismsTumor suppressorPoor overall survivalSuppressor geneDevelopment of adenomasImmunoglobulin domainHuman colorectal cancer
2019
c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth
Lyle C, Richards S, Yasuda K, Napoleon M, Walker J, Arinze N, Belghasem M, Vellard I, Yin W, Ravid J, Zavaro E, Amraei R, Francis J, Phatak U, Rifkin I, Rahimi N, Chitalia V. c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth. Scientific Reports 2019, 9: 20257. PMID: 31882749, PMCID: PMC6934810, DOI: 10.1038/s41598-019-56208-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesColorectal NeoplasmsGene Expression Regulation, NeoplasticHumansMacrophagesMice, KnockoutPhosphorylationProgrammed Cell Death 1 ReceptorProteasome Endopeptidase ComplexProto-Oncogene Proteins c-cblTumor BurdenTumor MicroenvironmentUbiquitinationUbiquitin-Protein LigasesConceptsPD-1Immune cellsTumor microenvironmentColorectal cancerCell death 1 proteinPD-1 regulationDeath 1 proteinImmune checkpoint receptorsColorectal tumor growthC-CblCasitas B lymphomaCRC xenograftsImmune checkpointsCheckpoint receptorsAutoimmune diseasesT lymphocytesTumor suppressive activitySuppressive activityTumor phagocytosisTumor growthFinger functionB lymphomaHigh expressionMiceXenografts