2023
Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity
Lotfollahzadeh S, Xia C, Amraei R, Hua N, Kandror K, Farmer S, Wei W, Costello C, Chitalia V, Rahimi N. Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Molecular Metabolism 2023, 73: 101744. PMID: 37245847, PMCID: PMC10267597, DOI: 10.1016/j.molmet.2023.101744.Peer-Reviewed Original ResearchConceptsMTOR activationHigh-fat dietObesity-associated diseasesGlucose toleranceKO miceChronic diseasesPathophysiological roleBody fatMetabolic disordersHypertrophic adipocytesKnockout miceObesityAdipose tissuePhysiological negative regulatorType 2HEK-293 cellsImpaired expressionComplex disorderCell culture studiesAdipocytesDiseaseMiceDisordersMTORUnknown role
2019
c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth
Lyle C, Richards S, Yasuda K, Napoleon M, Walker J, Arinze N, Belghasem M, Vellard I, Yin W, Ravid J, Zavaro E, Amraei R, Francis J, Phatak U, Rifkin I, Rahimi N, Chitalia V. c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth. Scientific Reports 2019, 9: 20257. PMID: 31882749, PMCID: PMC6934810, DOI: 10.1038/s41598-019-56208-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesColorectal NeoplasmsGene Expression Regulation, NeoplasticHumansMacrophagesMice, KnockoutPhosphorylationProgrammed Cell Death 1 ReceptorProteasome Endopeptidase ComplexProto-Oncogene Proteins c-cblTumor BurdenTumor MicroenvironmentUbiquitinationUbiquitin-Protein LigasesConceptsPD-1Immune cellsTumor microenvironmentColorectal cancerCell death 1 proteinPD-1 regulationDeath 1 proteinImmune checkpoint receptorsColorectal tumor growthC-CblCasitas B lymphomaCRC xenograftsImmune checkpointsCheckpoint receptorsAutoimmune diseasesT lymphocytesTumor suppressive activitySuppressive activityTumor phagocytosisTumor growthFinger functionB lymphomaHigh expressionMiceXenografts