2024
Stress and substance use disorders: risk, relapse, and treatment outcomes
Sinha R. Stress and substance use disorders: risk, relapse, and treatment outcomes. Journal Of Clinical Investigation 2024, 134: e172883. PMID: 39145454, PMCID: PMC11324296, DOI: 10.1172/jci172883.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug-related environmentPathophysiology of addictionAdaptive stress responseSUD treatment outcomesAssociated with substance misuseTreatment outcomesStress-related alterationsDrug motivationIncreased cravingNeurobiological disruptionsMaladaptive copingRepeated stressorsTreatment implicationsSubstance misuseStress pathophysiologyStress responseDrug intakeDrug withdrawalRelapse riskDrug misuseIntervention developmentDisordersCravingRelapse
2018
98. Effects of Childhood Maltreatment on Neural and Biobehavioral Biomarkers of Relapse and Recovery in Substance Use Disorders
Sinha R, Seo D, Lacadie C, Constable T, Hermes G. 98. Effects of Childhood Maltreatment on Neural and Biobehavioral Biomarkers of Relapse and Recovery in Substance Use Disorders. Biological Psychiatry 2018, 83: s40. DOI: 10.1016/j.biopsych.2018.02.116.Peer-Reviewed Original Research7 Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development
Fox H, Milivojevic V, Blaine S, Sinha R. 7 Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders—Targets for Medications Development. 2018, 120-141. DOI: 10.1016/b978-0-12-813693-5.00007-1.Peer-Reviewed Original ResearchMedication developmentDrug useAlpha-2 adrenergic agonistsStress system dysregulationStress-induced cravingPreclinical dataSystem dysregulationAdrenergic agonistsDrug AdministrationEarly abstinenceBiobehavioral mechanismsBiobehavioral adaptationsDysphoric statesNovel targetSubstance useRelapseAbstinenceNew foodsSeries of studiesUrgent needMedicationsGuanfacineAgonistsHuman paradigm
2017
Chronic alcohol-related neural and peripheral stress system dysfunction: Effects on alcohol craving, relapse and recovery
Sinha R. Chronic alcohol-related neural and peripheral stress system dysfunction: Effects on alcohol craving, relapse and recovery. Alcohol 2017, 60: 212. DOI: 10.1016/j.alcohol.2017.02.222.Peer-Reviewed Original Research
2006
Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ. Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes. JAMA Psychiatry 2006, 63: 324-331. PMID: 16520439, DOI: 10.1001/archpsyc.63.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultBehavior, AddictiveCocaine-Related DisordersCuesFemaleFollow-Up StudiesHospitalizationHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemProspective StudiesSecondary PreventionStress, PsychologicalSubstance Abuse Treatment CentersTreatment OutcomeConceptsAdrenal axis responseCocaine cravingRelapse outcomesAxis responseCocaine relapseAdrenal responseInpatient treatmentCocaine relapse outcomesCue-induced cocaine cravingStress-induced drug cravingCocaine useCocaine dependenceCox proportional hazards regressionCommunity mental health centerProportional hazards regressionMental health centersProspective study designDrug cue exposureStress-related increasesTreatment-seeking cocaine dependent individualsHazards regressionHypothalamic-PituitaryHealth centersCocaine-dependent individualsRelapse
2001
How does stress increase risk of drug abuse and relapse?
Sinha R. How does stress increase risk of drug abuse and relapse? Psychopharmacology 2001, 158: 343-359. PMID: 11797055, DOI: 10.1007/s002130100917.Peer-Reviewed Original ResearchConceptsDrug abuseSubstance abuseMost major theoriesHuman laboratory studiesField of addictionDrug seekingDrug useTreatment developmentMajor theoriesAbuse altersStress exposureVulnerable individualsHuman researchAbuseAddictsEmpirical evidencePreclinical evidenceClinical observationsRelapseAnimal studiesPreclinical researchSeekingGreater understandingAddictionResearch