2023
Sex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder
Smith K, Lacadie C, Milivojevic V, Fogelman N, Sinha R. Sex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder. Drug And Alcohol Dependence 2023, 244: 109794. PMID: 36758371, PMCID: PMC10024802, DOI: 10.1016/j.drugalcdep.2023.109794.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug cuesFuture drug useDrug use daysCue exposureNeural responsesUse daysSex differencesVentromedial prefrontal cortexScript-driven imageryDrug cue exposureNeutral cue exposureWhole-brain analysisWhole-brain correlationUse disordersDrug use outcomesCue-induced anxietyBrain responsesHeart rateFMRI scansPrefrontal cortexDrug cravingDrug useBrain analysisBrain correlations
2006
Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ. Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes. JAMA Psychiatry 2006, 63: 324-331. PMID: 16520439, DOI: 10.1001/archpsyc.63.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultBehavior, AddictiveCocaine-Related DisordersCuesFemaleFollow-Up StudiesHospitalizationHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemProspective StudiesSecondary PreventionStress, PsychologicalSubstance Abuse Treatment CentersTreatment OutcomeConceptsAdrenal axis responseCocaine cravingRelapse outcomesAxis responseCocaine relapseAdrenal responseInpatient treatmentCocaine relapse outcomesCue-induced cocaine cravingStress-induced drug cravingCocaine useCocaine dependenceCox proportional hazards regressionCommunity mental health centerProportional hazards regressionMental health centersProspective study designDrug cue exposureStress-related increasesTreatment-seeking cocaine dependent individualsHazards regressionHypothalamic-PituitaryHealth centersCocaine-dependent individualsRelapse